Zobrazeno 1 - 10
of 1 339
pro vyhledávání: '"protein oligomerization"'
Autor:
Raffaella Bonavita, Rosaria Di Martino, Giuseppe Cortone, Antonello Prodomo, Mariagrazia Di Gennaro, Gianluca Scerra, Valentino Panico, Silvia Nuzzo, Marco Salvatore, Sarah V. Williams, Fulvia Vitale, Maria Gabriella Caporaso, Massimo D’Agostino, Francesca M. Pisani, Angeleen Fleming, Maurizio Renna
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Conformational diseases, such as Alzheimer’s, Parkinson’s and Huntington’s diseases as well as ataxias and fronto-temporal disorders, are part of common class of neurological disorders characterised by the aggregation and progressive accumulati
Externí odkaz:
https://doaj.org/article/500eda45a45f4427980a64fda0c9ab07
Autor:
Kristen A. Johnson, Melissa R. Budicini, Nisha Bhattarai, Tej Sharma, Sarah Urata, Bernard S. Gerstman, Prem P. Chapagain, Sheng Li, Robert V. Stahelin
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100512- (2024)
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a peripheral binding protein that forms a shell beneath the lipid bilayer in vi
Externí odkaz:
https://doaj.org/article/8a3341cab06f4c60a01e5ef7dbe9ff15
Autor:
Anton A. Polyansky, Roman G. Efremov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2837-2844 (2023)
Constitutive activation of receptor tyrosine kinases (RTKs) via different mutations has a strong impact on the development of severe human disorders, including cancer. Here we propose a putative activation scenario of RTKs, whereby transmembrane (TM)
Externí odkaz:
https://doaj.org/article/3cfc5c0f05ee4332a9192921723d8901
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-17 (2022)
Highlights 1. High-throughput screening of ATG4B inhibitors based on FDA-approved drug library 2. Ebselen can covalently bind to ATG4B at Cys74 3. Ebselen can promote ATG4B oligomerization at Cys292 and Cys361 4. Ebselen suppresses the growth of colo
Externí odkaz:
https://doaj.org/article/16127599ceb44408b217c93e790335c2
Akademický článek
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Autor:
Mitu C. Acharjee, Brad Ledden, Brian Thomas, Xianglan He, Troy Messina, Jason Giurleo, David Talaga, Jiali Li
Publikováno v:
Sensors, Vol 24, Iss 1, p 81 (2023)
Protein aggregation is linked to many chronic and devastating neurodegenerative human diseases and is strongly associated with aging. This work demonstrates that protein aggregation and oligomerization can be evaluated by a solid-state nanopore metho
Externí odkaz:
https://doaj.org/article/244691a9697b42c3abc551c1a24af58b
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Bacteria could survive stresses by a poorly understood mechanism that contributes to the emergence of bacterial persisters exhibiting multidrug tolerance (MDT). Recently, Pseudoalteromonas rubra prpAT module was found to encode a toxin PrpT and corre
Externí odkaz:
https://doaj.org/article/3ad7e153a11f47d49b40f5ed01c7fd8e
Akademický článek
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Akademický článek
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Quantitative and kinetic single-molecule analysis of DNA unwinding by Escherichia coli UvrD helicase
Autor:
Hiroaki Yokota
Publikováno v:
Biophysics and Physicobiology, Vol 19 (2022)
Helicases are nucleic acid-unwinding enzymes involved in the maintenance of genome integrity. Helicases share several “helicase motifs” that are highly conserved amino acid sequences and are classified into six superfamilies (SFs). The helicase S
Externí odkaz:
https://doaj.org/article/3c45e2a04f534269b8a812681e001425