Zobrazeno 1 - 10
of 5 884
pro vyhledávání: '"protein misfolding"'
Autor:
Laetitia F. Heid, Emil Dandanell Agerschou, Asuka A. Orr, Tatsiana Kupreichyk, Walfried Schneider, Michael M. Wördehoff, Melanie Schwarten, Dieter Willbold, Phanourios Tamamis, Matthias Stoldt, Wolfgang Hoyer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 417-430 (2024)
β-Structure-rich amyloid fibrils are hallmarks of several diseases, including Alzheimer’s (AD), Parkinson’s (PD), and type 2 diabetes (T2D). While amyloid fibrils typically consist of parallel β-sheets, the anti-parallel β-hairpin is a structu
Externí odkaz:
https://doaj.org/article/41def2bd09194e848abe840a29fb7370
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 9, Pp 9342-9358 (2024)
Most neurodegenerative diseases share a common etiopathogenesis, the accumulation of protein aggregates. An imbalance in homeostasis brought on by the buildup of misfolded proteins within the endoplasmic reticulum (ER) results in ER stress in the cel
Externí odkaz:
https://doaj.org/article/0f1436b37d9f421297e80442da1d0d8b
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Drug-induced cardiotoxicity (DICT) poses a significant challenge in the prognosis of cancer patients, particularly with the use of antineoplastic agents like anthracyclines and targeted therapies such as trastuzumab. This review delves into the intri
Externí odkaz:
https://doaj.org/article/0cc9b221c415458fbfb59f1990cc3e0d
Autor:
Andreas Tapia-Arellano, Pablo Cabrera, Elizabeth Cortés-Adasme, Ana Riveros, Natalia Hassan, Marcelo J. Kogan
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-29 (2024)
Abstract The use of nanomaterials in medicine offers multiple opportunities to address neurodegenerative disorders such as Alzheimer's and Parkinson's disease. These diseases are a significant burden for society and the health system, affecting milli
Externí odkaz:
https://doaj.org/article/adebc24f747e49be98e0432737b4c43a
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-33 (2024)
Abstract Canavan disease is an autosomal recessive and lethal neurological disorder, characterized by the spongy degeneration of the white matter in the brain. The disease is caused by a deficiency of the cytosolic aspartoacylase (ASPA) enzyme, which
Externí odkaz:
https://doaj.org/article/d16159e3d96d4829b453b859feaeacf5
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Cellular protein homeostasis (proteostasis) plays an essential role in regulating the folding, sequestration, and turnover of misfolded proteins via a network of chaperones and clearance factors. Previous work has shown that misfolded proteins are sp
Externí odkaz:
https://doaj.org/article/295c7b18ab5746328fded05e17c0c05a
Autor:
Peter K. Stys, Shigeki Tsutsui, Arie R. Gafson, Bert A. ‘t Hart, Shibeshih Belachew, Jeroen J. G. Geurts
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Multiple sclerosis (MS) is a frequently disabling neurological disorder characterized by symptoms, clinical signs and imaging abnormalities that typically fluctuate over time, affecting any level of the CNS. Prominent lymphocytic inflammation, many g
Externí odkaz:
https://doaj.org/article/c57060beacc04081b04c01066f7e86ab
Autor:
Laura M Chamness, Charles P Kuntz, Andrew G McKee, Wesley D Penn, Christopher M Hemmerich, Douglas B Rusch, Hope Woods, Dyotima, Jens Meiler, Jonathan P Schlebach
Publikováno v:
eLife, Vol 12 (2024)
Many membrane proteins are prone to misfolding, which compromises their functional expression at the plasma membrane. This is particularly true for the mammalian gonadotropin-releasing hormone receptor GPCRs (GnRHR). We recently demonstrated that evo
Externí odkaz:
https://doaj.org/article/87e6dc4267994ade8aebd09e14ada9b5
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/f1839c52564b4545b4c39bc282eef3e1
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 11, Pp 2513-2521 (2024)
Amyotrophic lateral sclerosis is a neurodegenerative disease, and the molecular mechanism underlying its pathology remains poorly understood. However, inflammation is known to play an important role in the development of this condition. To identify d
Externí odkaz:
https://doaj.org/article/5a80e4b032f74cfe8251ce34d41c838e