Zobrazeno 1 - 10
of 1 224
pro vyhledávání: '"protein kinase C (PKC)"'
Autor:
Guanghan Ou, Akane Komura, Misaki Hojo, Rina Kato, Masahiro Ikeda, Miki Fujisawa, Keyue Xu, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 3, Pp 119-129 (2023)
We examined whether U46619 (a prostanoid TP receptor agonist) could enhance the contractions of guinea pig urinary bladder smooth muscle (UBSM) in response to acetylcholine (ACh) and an ATP analog (α,β-methylene ATP (αβ-MeATP)) through stimulatio
Externí odkaz:
https://doaj.org/article/399fcfd3f8a14d0ab0732f60693196b4
Autor:
Vadym Sulimenko, Vladimíra Sládková, Tetyana Sulimenko, Eduarda Dráberová, Věra Vosecká, Lubica Dráberová, Omar Skalli, Pavel Dráber
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Aggregation of high-affinity IgE receptors (FcϵRIs) on granulated mast cells triggers signaling pathways leading to a calcium response and release of inflammatory mediators from secretory granules. While microtubules play a role in the degranulation
Externí odkaz:
https://doaj.org/article/003031ad3b814540b79bed38311f12b0
Autor:
Nishtha Singh, Shouvik Kumar Nandy, Anupam Jyoti, Juhi Saxena, Aditi Sharma, Arif Jamal Siddiqui, Lalit Sharma
Publikováno v:
Brain Sciences, Vol 14, Iss 6, p 554 (2024)
Protein kinase C (PKC) is a diverse enzyme family crucial for cell signalling in various organs. Its dysregulation is linked to numerous diseases, including cancer, cardiovascular disorders, and neurological problems. In the brain, PKC plays pivotal
Externí odkaz:
https://doaj.org/article/0e5baa3ca01f4381939f82193e1c5523
Autor:
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent prote
Externí odkaz:
https://doaj.org/article/6905b40dd76244c5a441fae6f3e08a09
Autor:
Areeba Rehman, Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Janeen H. Trembley, Naeem Mahmood Ashraf, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili, Ali Alshamari, Tariq Nahar Alanezi, Suhail Razak
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background The protein kinase C (PKC) family of serine/threonine kinases contains more than ten isozymes that are involved in multiple signaling pathways, including cell cycle regulation and carcinogenesis. The PKCε isozyme is an oncogene k
Externí odkaz:
https://doaj.org/article/ca83bf0fa5f942b895d5fb2d3508a580
Publikováno v:
Journal of Functional Foods, Vol 99, Iss , Pp 105358- (2022)
Morus nigra L. is a traditional ethnomedicinal plants, which is used for the treatment of atherosclerosis, diabetes, hyperlipidemia, and hypertension. The aim of this study was to investigate the antidiabetic activity and potential mechanisms of ethy
Externí odkaz:
https://doaj.org/article/1cf24d6b0592436182621ed8f1f30f3e
Autor:
Byung Ju Lee, Jin Kwon Jeong
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/d4d35f5ce5aa44a9a9888c4d1dcd752a
Akademický článek
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Autor:
Sean Brennan, Simona Esposito, Muhammad I. M. Abdelaziz, Christopher A. Martin, Samir Makwana, Mark W. Sims, Iain B. Squire, Parveen Sharma, Amy E. Chadwick, Richard D. Rainbow
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Hyperglycaemia at the time of myocardial infarction has an adverse effect on prognosis irrespective of a prior diagnosis of diabetes, suggesting glucose is the damaging factor. In ex vivo models of ischaemia, we demonstrated that deleterious effects
Externí odkaz:
https://doaj.org/article/61cc3fe6d8c84613ac2712b76fa236b6
Publikováno v:
Physiological Reports, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract Stromal interaction molecule 1 (STIM1) is a major regulator of store‐operated calcium entry in non‐excitable cells. Recent studies have suggested that STIM1 plays a role in pathological hypertrophy; however, the physiological role of STI
Externí odkaz:
https://doaj.org/article/dd96fa0452b54f8c8ca4b8127bf5f810