Zobrazeno 1 - 10
of 15
pro vyhledávání: '"protein deacylation"'
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Sirtuins are NAD+-dependent deacylases that play crucial roles in the regulation of cellular metabolism, and as a result, are implicated in several diseases. The mitochondrial sirtuin Sirt4, for a long time considered as mainly a mono-ADP-ribosyltran
Externí odkaz:
https://doaj.org/article/40c9cb1ce54c419180e588e206bfb4bc
Publikováno v:
European Journal of Clinical Investigation. 50
Nicotinamide adenine dinucleotide (NAD+ ) is an essential metabolite in energy metabolism as well as a co-substrate in biochemical reactions such as protein deacylation, protein ADP-ribosylation and cyclic ADP-ribose synthesis mediated by sirtuins, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98e4fd8afc44b018fe4e4ba8c5a64117
https://doi.org/10.1111/eci.13334
https://doi.org/10.1111/eci.13334
Autor:
Leonard Guarente, Shin-ichiro Imai
Publikováno v:
Nature
The coupling of nicotinamide adenine dinucleotide (NAD⁺) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD⁺ and sirtuins has an ancient origin and provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e44163a43185c8568607756fafe342
https://doi.org/10.1038/npjamd.2016.17
https://doi.org/10.1038/npjamd.2016.17
Autor:
Hening Lin, Bin He
Publikováno v:
Sirtuins ISBN: 9789402409611
The human SIRT5 gene was first identified in 1999 using the sequence of yeast SIR2 protein (Frye RA, BiophysRes Commun 260:273–279, 1999). Sequence analysis suggests that it is more similar to prokaryotic sirtuins (Frye RA, BiophysRes Commun 260:27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19fbf9337971116af2413c9a1ba3384
https://doi.org/10.1007/978-94-024-0962-8_6
https://doi.org/10.1007/978-94-024-0962-8_6
Publikováno v:
Journal of Biological Chemistry. 287:42436-42443
The sirtuins are a family of NAD(+)-dependent protein deacetylases that regulate cell survival, metabolism, and longevity. Three sirtuins, SIRT3-5, localize to mitochondria. Expression of SIRT3 is selectively activated during fasting and calorie rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ff5a8dd2b48ec1d7ca96207bd62afb
https://doi.org/10.1074/jbc.r112.404863
https://doi.org/10.1074/jbc.r112.404863
Autor:
Aldo Alejandro Vilcaes, Maria P. Pedro, Guillermo A. Gomez, Vanesa M. Tomatis, Jose L. Daniotti, Rafael G. Oliveira
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 8, Iss 10, p e75232 (2013)
PLoS ONE
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 8, Iss 10, p e75232 (2013)
PLoS ONE
S-acylation, the covalent attachment of palmitate and other fatty acids on cysteine residues, is a reversible post-translational modification that exerts diverse effects on protein functions. S-acylation is catalyzed by protein acyltransferases (PAT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0d1617a02858c2c12f968b4ff5f4af
https://hdl.handle.net/11541.2/126460
https://hdl.handle.net/11541.2/126460
Autor:
Joel M. Gottesfeld, John M. Denu
The sirtuins are an ancient family of proteins found in all forms of life, displaying a structure and catalytic function that has been maintained from bacteria to humans. In an NAD+-dependent process, sirtuins perform protein deacylation from lysine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bc8e2c03e5d829e8ed93394a3a4dce
https://europepmc.org/articles/PMC3522241/
https://europepmc.org/articles/PMC3522241/
Autor:
Dongming Qian, Bruce G. Szczepankiewicz, Fan Jiang, Karsten Koppetsch, Han Dai, Robert B. Perni, Cheney Mao
Publikováno v:
The Journal of organic chemistry. 77(17)
Carba-NAD is a synthetic compound identical to NAD except for one substitution, where an oxygen atom adjacent to the anomeric linkage bearing nicotinamide is replaced with a methylene group. Because it is inert in nicotinamide displacement reactions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc995cdc72dab5eb7346250c0c5986f
https://pubmed.ncbi.nlm.nih.gov/22849721
https://pubmed.ncbi.nlm.nih.gov/22849721
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15045 (2010)
PLoS ONE
PLoS ONE
An acylation/deacylation cycle is necessary to maintain the steady-state subcellular distribution and biological activity of S-acylated peripheral proteins. Despite the progress that has been made in identifying and characterizing palmitoyl-transfera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d358724a28bbb1e31379373a93d7e7
https://hdl.handle.net/11541.2/126512
https://hdl.handle.net/11541.2/126512
Autor:
Tzu-Hui Hsu, Tsu-Chung Chang
Publikováno v:
Molecular & Cellular Oncology
We recently reported that retinoic acid receptor responder 3 (RARRES3)-mediated protein deacylation resulted in significant inhibition of the transformed properties of breast cancer cells. This finding suggests a key role of RARRES3 in the regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d15eadb335b6503700f0b6ed1ed0850
https://doi.org/10.1080/23723556.2014.999512
https://doi.org/10.1080/23723556.2014.999512