Zobrazeno 1 - 10
of 47
pro vyhledávání: '"protein burden"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 3229-3242 (2020)
Cell growth is driven by the synthesis of proteins, genes, and other cellular components. Defining processes that limit biosynthesis rates is fundamental for understanding the determinants of cell physiology. Here, we analyze the consequences of engi
Externí odkaz:
https://doaj.org/article/275a0954350e4176a663abe0f85afd4a
Autor:
Reiko Kintaka, Koji Makanae, Shotaro Namba, Hisaaki Kato, Keiji Kito, Shinsuke Ohnuki, Yoshikazu Ohya, Brenda J Andrews, Charles Boone, Hisao Moriya
Publikováno v:
eLife, Vol 9 (2020)
Overproduction (op) of proteins triggers cellular defects. One of the consequences of overproduction is the protein burden/cost, which is produced by an overloading of the protein synthesis process. However, the physiology of cells under a protein bu
Externí odkaz:
https://doaj.org/article/e6787edb0fe14313bbb3ee62e8ff839b
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 22-31 (2016)
The economy of protein production is central to cell physiology, being intimately linked with cell division rate and cell size. Attempts to model cellular physiology are limited by the scarcity of experimental data defining the molecular processes li
Externí odkaz:
https://doaj.org/article/6aed5c3335314c80844ffd181c6c90f9
Autor:
Benedetta Bolognesi, Ben Lehner
Publikováno v:
eLife, Vol 7 (2018)
How many copies of a protein can be made before it becomes toxic to the cell?
Externí odkaz:
https://doaj.org/article/9ff1cc63b4d74f6989851cd8742ed4a9
Publikováno v:
eLife, Vol 7 (2018)
The ultimate overexpression of a protein could cause growth defects, which are known as the protein burden. However, the expression limit at which the protein-burden effect is triggered is still unclear. To estimate this limit, we systematically meas
Externí odkaz:
https://doaj.org/article/e0a64d5f20db440ca7ad074a50a78832
Autor:
Zoltán Farkas, Dorottya Kalapis, Zoltán Bódi, Béla Szamecz, Andreea Daraba, Karola Almási, Károly Kovács, Gábor Boross, Ferenc Pál, Péter Horváth, Tamás Balassa, Csaba Molnár, Aladár Pettkó-Szandtner, Éva Klement, Edit Rutkai, Attila Szvetnik, Balázs Papp, Csaba Pál
Publikováno v:
eLife, Vol 7 (2018)
Proteins are necessary for cellular growth. Concurrently, however, protein production has high energetic demands associated with transcription and translation. Here, we propose that activity of molecular chaperones shape protein burden, that is the f
Externí odkaz:
https://doaj.org/article/6f8039d030b34e66ac201c61828ad227
Publikováno v:
G3 (Bethesda, Md.). 12(6)
The enhanced green fluorescent protein (EGFP) is considered to be a harmless protein because the critical expression level that causes growth defects is higher than that of other proteins. Here, we found that overexpression of EGFP, but not a glycoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b112e4154c1244979e2910bbbcd5c981
https://pubmed.ncbi.nlm.nih.gov/35485947
https://pubmed.ncbi.nlm.nih.gov/35485947
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Berg, Otto G.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1992 Aug . 89(16), 7501-7505.
Externí odkaz:
https://www.jstor.org/stable/2360118
Autor:
Yoshikazu Ohya, Reiko Kintaka, Brenda J. Andrews, Shotaro Namba, Koji Makanae, Hisao Moriya, Charles Boone, Shinsuke Ohnuki, Hisaaki Kato, Keiji Kito
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Overproduction (op) of proteins triggers cellular defects. One of the consequences of overproduction is the protein burden/cost, which is produced by an overloading of the protein synthesis process. However, the physiology of cells under a protein bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737d25315481a37ea24829b9036a4693
https://pubmed.ncbi.nlm.nih.gov/33146608
https://pubmed.ncbi.nlm.nih.gov/33146608