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In Silico Drug Design and Analysis of Dual Amyloid-Beta and Tau Protein-Aggregation Inhibitors for Alzheimer's Disease Treatment.

Autor: Job, Nisha¹ (AUTHOR), Thimmakondu, Venkatesan S.² (AUTHOR) vthimmakondusamy@sdsu.edu, Thirumoorthy, Krishnan¹ (AUTHOR) vthimmakondusamy@sdsu.edu

Publikováno v: Molecules. Feb2023, Vol. 28 Issue 3, p1388. 13p.

Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases

Autor: Eiko N. Minakawa, Yoshitaka Nagai

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

The polyglutamine (polyQ) diseases are a group of inherited neurodegenerative diseases caused by the abnormal expansion of a CAG trinucleotide repeat that are translated into an expanded polyQ stretch in the disease-causative proteins. The expanded p

Externí odkaz: https://doaj.org/article/3665275c72bc4158b7a14ab29d084360

Glycans to improve efficacy and solubility of protein aggregation inhibitors

Autor: Ashim Paul, Daniel Segal, Elsa Zacco

Publikováno v: Neural Regeneration Research, Vol 16, Iss 11, Pp 2215-2216 (2021)

Externí odkaz: https://doaj.org/article/c8acd4efbee849ebbd4b5247c493092d

Glycans to improve efficacy and solubility of protein aggregation inhibitors.

Autor: Paul A; Department of Molecular Microbiology and Biotechnology, Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Ramat Aviv, Tel Aviv 6997801, Israel., Segal D; Department of Molecular Microbiology and Biotechnology, Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Ramat Aviv, Tel Aviv 6997801, Israel., Zacco E; RNA Central Lab, Center for Human Technologies, Istituto Italiano di Tecnologia, 16152 Genova, Italy.

Publikováno v: Neural regeneration research [Neural Regen Res] 2021 Nov; Vol. 16 (11), pp. 2215-2216.