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of 77
pro vyhledávání: '"protein TDP-43"'
Publikováno v:
Neurobiology of Disease, Vol 196, Iss , Pp 106516- (2024)
Hyperphosphorylated TAR DNA-binding protein 43 (TDP-43) aggregates in the cytoplasm of neurons is the neuropathological hallmark of amyotrophic lateral sclerosis (ALS) and a group of neurodegenerative diseases collectively referred to as TDP-43 prote
Externí odkaz:
https://doaj.org/article/d52bed0e88e44065b4f372916bf8d8e0
Akademický článek
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Publikováno v:
Brain and Behavior, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract Background Targeting leptin could represent a rational strategy to treat amyotrophic lateral sclerosis (ALS), as previously clinical studies have shown its levels to be associated with a lower risk of ALS disease. However, very little is kno
Externí odkaz:
https://doaj.org/article/b74c2edd61e34c5c828437af6c1f7982
Autor:
Agueda Ferrer-Donato, Ana Contreras, Laura M. Frago, Julie A. Chowen, Carmen M. Fernandez-Martos
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10305 (2021)
Leptin has been suggested to play a role in amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disease. This adipokine has previously been shown to be associated with a lower risk of ALS and to confer a survival advantage in A
Externí odkaz:
https://doaj.org/article/36b84b1527a546a0b412bfc77719a7d9
Autor:
César Álvaro-Alonso, Águeda Ferrer-Donato, Elizabeth Fernández-Torres, Mónica Carballo-Villa, Carmen M. Fernandez-Martos
Publikováno v:
Animals, Vol 10, Iss 12, p 2329 (2020)
The use of genetically engineered mouse (GEMs) models provides an unprecedented opportunity to study the genetic basis of diseases and gene function, therefore it is paramount to determine reproductive parameters that guarantee proper colony maintena
Externí odkaz:
https://doaj.org/article/43ee45e3f80e4e4e86dca63f4ecfcc8a
Publikováno v:
AIMS Molecular Science, Vol 3, Iss 2, Pp 246-268 (2016)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motoneuron degeneration. The features observed in ALS are the mislocalization and aggregation of proteins in the affected motoneurons. The mutants of Cu/Zn superoxide
Externí odkaz:
https://doaj.org/article/d4f93b1155c246e29e1ee491b453a891
Autor:
Kimiko Inoue, Harutoshi Fujimura, Keiko Toyooka, Makito Hirano, Yusaku Nakamura, Saburo Sakoda
Publikováno v:
Cogent Medicine, Vol 5, Iss 1 (2018)
We described an autopsied case of amyotrophic lateral sclerosis (ALS)-dementia with p.R487H mutation in the VCP gene. TDP-43-positive neuronal cytoplasmic inclusions (NCI), neuronal intranuclear inclusions (NII) and glial cytoplasmic inclusions were
Externí odkaz:
https://doaj.org/article/6898ec912512456fab89b318e08cc3bd
Publikováno v:
Journal of Molecular Cell Biology
Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease selectively affecting motor neurons, leading to progressive paralysis. Although most cases are sporadic, ∼10% are familial. Similar proteins are found in aggregates in sp
Publikováno v:
J Neuropathol Exp Neurol
Bulbar amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative subtype affecting speech and swallowing motor functions as well as associated with the burden of cognitive deficits. The neuroanatomical underpinnings of bulbar ALS are no
Publikováno v:
Brain and Behavior
Brain and Behavior, Vol 12, Iss 1, Pp n/a-n/a (2022)
Brain and Behavior, Vol 12, Iss 1, Pp n/a-n/a (2022)
Background Targeting leptin could represent a rational strategy to treat amyotrophic lateral sclerosis (ALS), as previously clinical studies have shown its levels to be associated with a lower risk of ALS disease. However, very little is known about