DNA demethylation agent 5azadC downregulates HPV16 E6 expression in cervical cancer cell lines independently of TBX2 expression

Autor: Celine Mourareau, David Guenat, Sylvie Fauconnet, Philippe Paget-Bailly, Christiane Mougin, Aurélie Baguet, Adrien Morel, Christine Clavel, Jean Luc Prétet, Koceila Meznad, Jérôme Perrard, Véronique Dalstein

Publikováno v: Oncology Letters
Oncology Letters, Spandidos Publications, 2019, 108, pp.15-18. ⟨10.3892/ol.2019.11158⟩
Oncology Letters, 2019, 108, pp.15-18. ⟨10.3892/ol.2019.11158⟩
Oncology Letters, Spandidos Publications, 2019, ⟨10.3892/ol.2019.11158⟩
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

HPV16 is the most carcinogenic human papillomavirus and causes >50% of cervical cancers, the majority of anal cancers and 30% of oropharyngeal squamous cell carcinomas. HPV carcinogenesis relies on the continuous expression of the two main viral onco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3bbd25a2bffb3b761a230717ddd211
https://doi.org/10.3892/ol.2019.11158

The HPV16 oncogenes cause aberrant stem cell mobilization

Autor: Michael, S., Lambert, P. F., Strati, K.

Publikováno v: Virology

Human Papilloma Virus related epithelial cancers have been speculated to derive from virus-infected tissue stem cells. Stem cells also are thought to provide a reservoir of latently infected cells that can persist for long periods. In this study we h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99dc1d3e92b09923c41c4e380db8ed5

Human Papillomavirus Type 16 E6 and E7 Oncoproteins Act Synergistically to Cause Head and Neck Cancer in Mice

Autor: Jabbar, S., Strati, K., Shin, M. K., Pitot, H. C., Lambert, P. F.

Publikováno v: Virology

High-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers, and they are also linked etiologically to a subset of head and neck squamous cell carcinomas (HNSCC). We previously established a model for HPV-associated HN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936b6c2e60cafb2029d89d6934706cfa
https://europepmc.org/articles/PMC2946459/

Novel anti-metastatic action of cidofovir mediated by inhibition of E6/E7, CXCR4 and Rho/ROCK signaling in HPV+ tumor cells

Autor: Marie-Catherine Vozenin-Brotons, Hakim Bouamar, Paule Opolon, Jean Bourhis, Abdessamad Amine, Sofia Rivera, Mehdi Dekkal, Denis Biard, Fawzia Louache, Michael J. McKay, Eric Deutsch

Publikováno v: PLoS ONE
PLoS ONE, 2009, 4 (3), ⟨10.1371/journal.pone.0005018⟩
PLoS ONE, Public Library of Science, 2009, 4 (3), ⟨10.1371/journal.pone.0005018⟩
PLoS ONE, Vol 4, Iss 3, p e5018 (2009)

Cervical cancer is frequently associated with HPV infection. The expression of E6 and E7 HPV oncoproteins is a key factor in its carcinogenicity and might also influence its virulence, including metastatic conversion. The cellular mechanisms involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90044bac30d3ad9f2693fc017435a918
https://hal.science/hal-02985060

Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer

Autor: Strati, K., Lambert, P. F.

Publikováno v: Cancer research
Cancer Res.

Infection with high-risk human papillomaviruses (HPV) and in particular the expression of the viral proteins E6 and E7 have been associated with the etiology of a subset of head and neck squamous cell cancer (HNSCC). However, the individual consequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68e0b27a17204770303a285f0de1abb
http://gnosis.library.ucy.ac.cy/handle/7/53409