Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1

Autor: Shinya Tashiro, Chie Motono, Kenichiro Imai, Waka Kojima, Kouhei Tsumoto, Mayumi Kimura, Jose M. M. Caaveiro, Noriyuki Matsuda, Chisato Udagawa, Bruno B. Queliconi, Takatsugu Hirokawa, Keiji Tanaka, Koji Yamano

Publikováno v: Journal of Cell Science
article-version (VoR) Version of Record

Diverse genes associated with familial Parkinson's disease (familial Parkinsonism) have been implicated in mitochondrial quality control. One such gene, PARK7 encodes the protein DJ-1, pathogenic mutations of which trigger its translocation from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b7c26a90bd3f495b8f8e5e41c67d9b
https://doi.org/10.1242/jcs.258653

miR-181a regulates p62/SQSTM1, parkin, and protein DJ-1 promoting mitochondrial dynamics in skeletal muscle aging

Autor: Rachel McCormick, Brian McDonagh, Caroline Chinda, Katarzyna Goljanek-Whysall, Ana Soriano-Arroquia

Publikováno v: Aging Cell
AGING CELL

One of the key mechanisms underlying skeletal muscle functional deterioration during aging is disrupted mitochondrial dynamics. Regulation of mitochondrial dynamics is essential to maintain a healthy mitochondrial population and prevent the accumulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b156711fdb9fddc750b9ef7c6a5ffd54
https://pubmed.ncbi.nlm.nih.gov/32291905

Chemical Probe To Monitor the Parkinsonism-Associated Protein DJ-1 in Live Cells

Autor: Stephan A. Sieber, Franziska A. Mandl, Jonas Drechsel

Publikováno v: ACS Chemical Biology. 13:2016-2019

Reactive oxygen species (ROS) play an important role in the onset of Parkinson's disease (PD), and deciphering protective mechanisms is a major goal for therapeutic development. Here, DJ-1 (PARK7) gained major attention when a conserved cysteine resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d347699debc366211451a9564e44a10
https://doi.org/10.1021/acschembio.8b00633

Parkinson's disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth

Autor: Agnita J.W. Boon, Han-A Park, Vincenzo Bonifati, Wim Mandemakers, Pawel Licznerski, Jack Tang, Nelli Mnatsakanyan, Morven Graham, Yulong Niu, Rongmin Chen, Giovanni Cossu, Jing Wu, Elizabeth A. Jonas, Peter K. Smith, Kambiz N. Alavian, Paige Miranda

Publikováno v: Cell Death & Disease
Cell death & disease, 10:469. Nature Publishing Group
Cell Death and Disease, Vol 10, Iss 6, Pp 1-12 (2019)
BASE-Bielefeld Academic Search Engine

Familial Parkinson’s disease (PD) protein DJ-1 mutations are linked to early onset PD. We have found that DJ-1 binds directly to the F1FO ATP synthase β subunit. DJ-1’s interaction with the β subunit decreased mitochondrial uncoupling and enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc74e1988a7a6d2b63644613555ffc19
https://hdl.handle.net/1765/117378

Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1

Autor: Aki Tanabe, Yasushi Tamura, Jose M. M. Caaveiro, Shinya Tashiro, Noriyuki Matsuda, Satoru Nagatoishi, Kouhei Tsumoto, Dali Liu, Quyen Q. Hoang, Makoto Nakakido

Publikováno v: ACS chemical biology. 13(9)

DJ-1 is a Parkinson's disease associated protein endowed with enzymatic, redox sensing, regulatory, chaperoning, and neuroprotective activities. Although DJ-1 has been vigorously studied for the past decade and a half, its exact role in the progressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538f8c7d2317fd63a24ba5c99f0b73bf
https://pubmed.ncbi.nlm.nih.gov/30063823