Zobrazeno 1 - 10
of 50 601
pro vyhledávání: '"protein–protein interaction"'
Autor:
Bin-Bin Zhang, Yi-Lin Zhao, Yan-Yu Lu, Ji-Hong Shen, Hui-Yong Li, Han-Xue Zhang, Xiao-Yue Yu, Wen-Cai Zhang, Gang Li, Zhan-Ying Han, Sen Guo, Xu-Tao Zhang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Pathological cardiac hypertrophy is the primary cause of heart failure, yet its underlying mechanisms remain incompletely understood. Transmembrane protein 100 (TMEM100) plays a role in various disorders, such as nervous system disease, pain
Externí odkaz:
https://doaj.org/article/a166752f3b794a1392a154e1182a495a
Autor:
Eleftheria Vasilaki, Yu Bai, Mohamad Moustafa Ali, Anders Sundqvist, Aristidis Moustakas, Carl-Henrik Heldin
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background p63 is a transcription factor with intrinsic pioneer factor activity and pleiotropic functions. Transforming growth factor β (TGFβ) signaling via activation and cooperative action of canonical, SMAD, and non-canonical, MAP-kinas
Externí odkaz:
https://doaj.org/article/c69b2398770746ad995d89ef0e1932d9
Autor:
Dominik Dluhosch, Lisa Sophie Kersten, Stephan Schott-Verdugo, Claudia Hoppen, Melanie Schwarten, Dieter Willbold, Holger Gohlke, Georg Groth
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Copper chaperones of the ATX1 family are found in a wide range of organisms where these essential soluble carriers strictly control the transport of monovalent copper across the cytoplasm to various targets in diverse cellular compartments t
Externí odkaz:
https://doaj.org/article/2ea017596ca742f9997a535d79d6ed67
Autor:
Kesheng Li, Dandan Chai, Shiyang Ren, Xiaowen Lian, Xiaoling Shi, Yang Xu, Lie Bao, Suisheng Yang, Yurong Liang, Xiaoqin Li, Huifen Du
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Our previous study demonstrated that β2-microglobulin (β2M) promoted ER+/HER2– breast cancer survival via the SGK1/Bcl-2 signaling pathway. However, the role of β2M has not been investigated in ER–/HER2+ breast cancer. Here
Externí odkaz:
https://doaj.org/article/c9007b550ae04b5b939397f324d7d403
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Although rheumatoid arthritis (RA) is a chronic systemic tissue disease often accompanied by osteoporosis (OP), the molecular mechanisms underlying this association remain unclear. This study aimed to elucidate the pathogenesis of
Externí odkaz:
https://doaj.org/article/07e1289b36b04b23976a6af055996416
Autor:
Johanna Kliche, Leandro Simonetti, Izabella Krystkowiak, Hanna Kuss, Marcel Diallo, Emma Rask, Jakob Nilsson, Norman E Davey, Ylva Ivarsson
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 9, Pp 1025-1048 (2024)
Abstract Whole genome and exome sequencing are reporting on hundreds of thousands of missense mutations. Taking a pan-disease approach, we explored how mutations in intrinsically disordered regions (IDRs) break or generate protein interactions mediat
Externí odkaz:
https://doaj.org/article/0bbc2585d8e5430193b425c67f6f3b23
Autor:
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika Vartak, Jiewei Xu, Jeffrey F DiBerto, Bryan L Roth, Manon Eckhardt, Mark von Zastrow, Nevan J Krogan, Ruth Hüttenhain
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 8, Pp 952-971 (2024)
Abstract Proximity labeling (PL) via biotinylation coupled with mass spectrometry (MS) captures spatial proteomes in cells. Large-scale processing requires a workflow minimizing hands-on time and enhancing quantitative reproducibility. We introduced
Externí odkaz:
https://doaj.org/article/b1fa4dc8556644079c79cd440ac3a387
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7353-7372 (2024)
Eriocheir sinensis is an economically important aquatic animal. Its regulatory mechanisms underlying many biological processes are still vague due to the lack of systematic analysis tools. The protein–protein interaction network (PIN) is an importa
Externí odkaz:
https://doaj.org/article/9cf6c41b38764ec2b06b715e35de3f49
Autor:
Marcell Miski, Áron Weber, Krisztina Fekete-Molnár, Bence Márk Keömley-Horváth, Attila Csikász-Nagy, Zoltán Gáspári
Publikováno v:
BMC Neuroscience, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background The postsynaptic density is an elaborate protein network beneath the postsynaptic membrane involved in the molecular processes underlying learning and memory. The postsynaptic density is built up from the same major proteins but i
Externí odkaz:
https://doaj.org/article/8fdc0d257f284adcaf10069240bd2c10
Publikováno v:
Plant Methods, Vol 20, Iss 1, Pp 1-13 (2024)
Abstract Background Optimization of a highly efficient transient expression system is critical for the study of gene function, particularly in those plants in which stable transformation methods are not widely available. Agrobacterium tumefaciens‑m
Externí odkaz:
https://doaj.org/article/4b979110d30e403f80d87ab458b4d50f