Zobrazeno 1 - 10
of 1 862
pro vyhledávání: '"proteasome inhibition"'
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 36, Iss 11, Pp 693-704 (2023)
DNA methylation is an important epigenetic mark required for proper gene expression and silencing of transposable elements. DNA methylation patterns can be modified by environmental factors such as pathogen infection, in which modification of DNA met
Externí odkaz:
https://doaj.org/article/9cafc0ab6da6458ebe8c6c6d2846efca
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-17 (2023)
Abstract Background Ubiquitin–proteasome-system-mediated clearance of misfolded proteins is essential for cells to maintain proteostasis and reduce the proteotoxicity caused by these aberrant proteins. When proteasome activity is inadequate, ubiqui
Externí odkaz:
https://doaj.org/article/556187ca21804285b3e04f5317ba8b7f
Publikováno v:
Marine Drugs, Vol 22, Iss 7, p 315 (2024)
Malignant melanoma—a tumor originating from melanocytes—is characterized by dynamic growth and frequent metastases in the early stage of development. Current therapy methods are still insufficient, and there is a need to search for new ways of tr
Externí odkaz:
https://doaj.org/article/5d25476a1c8a4ea590ef0fd7adcbd636
Autor:
Boranai Tychhon, Jesse C. Allen, Mayra A. Gonzalez, Idaly M. Olivas, Jonathan P. Solecki, Mehrshad Keivan, Vanessa V. Velazquez, Emily B. McCall, Desiree N. Tapia, Andres J. Rubio, Connor Jordan, David Elliott, Anna M. Eiring
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionThe ubiquitin-proteasome system (UPS) is an intracellular organelle responsible for targeted protein degradation, which represents a standard therapeutic target for many different human malignancies. Bortezomib, a reversible inhibitor of
Externí odkaz:
https://doaj.org/article/010cadc74b6644749c4de5cb87a7559c
Autor:
Azam Salimi, Kema Marlen Schroeder, Mirle Schemionek-Reinders, Margherita Vieri, Saskia Maletzke, Deniz Gezer, Behzad Kharabi Masouleh, Iris Appelmann
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background The therapeutic armamentarium in multiple myeloma has been significantly broadened by proteasome inhibitors, highly efficient means in controlling of multiple myeloma. Despite the developments of therapeutic regimen in treatment o
Externí odkaz:
https://doaj.org/article/f42d58a7ebfb4f15ad822fdc978a3f99
Autor:
Hericka Bruna Figueiredo Galvao, Quynh Nhu Dinh, Jordyn M. Thomas, Flavia Wassef, Henry Diep, Alex Bobik, Christopher G. Sobey, Grant R. Drummond, Antony Vinh
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionDepletion of mature B cells affords protection against experimental hypertension. However, whether B cell-mediated hypertension is dependent on differentiation into antibody-secreting cells (ASCs) remains unclear. Using the proteasome inh
Externí odkaz:
https://doaj.org/article/9c1030f86c7b434f860c0dea7c447266
Akademický článek
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Autor:
Fawzia Bardag-Gorce, Carter Hoffman, Imara Meepe, Monica Ferrini, Richard H. Hoft, Joan Oliva, Yutaka Niihara
Publikováno v:
Heliyon, Vol 9, Iss 2, Pp e13397- (2023)
The present study focuses on investigating the expression of thrombospondin-1 (TSP-1), a natural inhibitor of neovascularization. Immunofluorescent staining was used to detect the expression of TSP-1 in rabbit corneal tissue with vascularization indu
Externí odkaz:
https://doaj.org/article/b648bda6b58541deb9c03b036d1fc948
Autor:
Erica Torchiaro, Consalvo Petti, Sabrina Arena, Francesco Sassi, Giorgia Migliardi, Alfredo Mellano, Roberta Porporato, Marco Basiricò, Loretta Gammaitoni, Enrico Berrino, Monica Montone, Giorgio Corti, Giovanni Crisafulli, Caterina Marchiò, Alberto Bardelli, Enzo Medico
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
High-grade mucinous colorectal cancer (HGM CRC) is particularly aggressive, prone to metastasis and treatment resistance, frequently accompanied by “signet ring” cancer cells. A sizeable fraction of HGM CRCs (20-40%) arises in the context of the
Externí odkaz:
https://doaj.org/article/a4d991eacaeb4b91b2c17db7c0dd2e37
Autor:
Christopher J. Walker, Hua Chang, Leah Henegar, Trinayan Kashyap, Sharon Shacham, Josh Sommer, Michael J. Wick, Joan Levy, Yosef Landesman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chordoma is a rare cancer that grows in the base of the skull and along the mobile spine from remnants of embryonic notochord tissue. The cornerstone of current treatments is surgical excision with adjuvant radiation therapy, although complete surgic
Externí odkaz:
https://doaj.org/article/2439b9474a294b25943651078e71961a