Zobrazeno 1 - 10
of 785
pro vyhledávání: '"protease-activated receptor 1"'
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a 5-year survival rate of 6% following a diagnosis, and novel therapeutic modalities are needed. Protease-activated receptor 1 (PAR1) is abundantly overexpre
Externí odkaz:
https://doaj.org/article/c6596f5c0f934ffe888caea449003de4
Autor:
Ravinder Singh, Varinder Singh, Md. Altamash Ahmad, Chirag Pasricha, Pratima Kumari, Thakur Gurjeet Singh, Rupinder Kaur, Somdutt Mujwar, Tanveer A. Wani, Seema Zargar
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 454 (2024)
Inflammation is a distinguished clinical manifestation of COVID-19 and type 2 diabetes mellitus (T2DM), often associated with inflammatory dysfunctions, insulin resistance, metabolic dysregulation, and other complications. The present study aims to t
Externí odkaz:
https://doaj.org/article/d7ea81eae349449fa08b0d9b26ea9c72
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Sickle Cell Disease (SCD) is a group of inherited hemoglobinopathies. Sickle cell anemia (SCA) is caused by a homozygous mutation in the β-globin generating sickle hemoglobin (HbS). Deoxygenation leads to pathologic polymerization of HbS and sicklin
Externí odkaz:
https://doaj.org/article/fc49611b06a54c11b4cb65dbedae1fca
Autor:
Henriette Farkas, Csilla Máj, István Kenessey, Anna Sebestyén, Ildikó Krencz, Judit Pápay, László Cervenak
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 18, Iss 1, Pp 1-8 (2022)
Abstract Background Hereditary angioedema (HAE) is a rare, life-threatening disease. The knowledge about the molecular pathogenesis of HAE has derived mainly from investigating blood samples. However, limited data are available on the role of the mol
Externí odkaz:
https://doaj.org/article/029d483150c043a688edcc0810c0c4a7
Autor:
Cansu Tekin, Brendon P. Scicluna, Sophie C. Lodestijn, Kun Shi, Maarten F. Bijlsma, C. Arnold Spek
Publikováno v:
Molecular Oncology, Vol 15, Iss 11, Pp 3091-3108 (2021)
Pancreatic acinar cells have high plasticity and can transdifferentiate into ductal‐like cells. This acinar‐to‐ductal metaplasia (ADM) contributes to tissue maintenance but may also contribute to the premalignant transformation that can eventua
Externí odkaz:
https://doaj.org/article/655bec2113474b9fb2695cc8e9d4dd14
Autor:
Lu-Xi Zhou, Shao-Wei Lin, Rong-Hui Qiu, Ling Lin, Yue-Feng Guo, Dao-Shu Luo, Yun-Qing Li, Feng Wang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
IntroductionThe aim of this study was to investigate the effect and possible mechanisms of the blood-nerve barrier (BNB) and the coagulation-anticoagulation system in modulating the mechanical allodynia in a trigeminal neuralgia (TN) rat model induce
Externí odkaz:
https://doaj.org/article/1c36bacc8dee41ad9e57fd6a0cb6d91a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundChancre self-healing, a typical clinical phenomenon of primary syphilis, is essentially wound healing. The first response to a wound is constriction of the injured blood vessels and activation of platelets to form a fibrin clot. However, th
Externí odkaz:
https://doaj.org/article/ffaa78ff351849049ef2323f87f45f23
Akademický článek
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Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Protease-activated receptor (PAR)-1 is a thrombin-activated receptor that plays an essential role in ischemia/reperfusion (IR)-induced acute inflammation. PAR-1 antagonists have been shown to alleviate injuries in various IR models. However, the effe
Externí odkaz:
https://doaj.org/article/1e3098cce12e4faab9909e462ba425d5
Autor:
Patricia P. Wadowski, Joseph Pultar, Constantin Weikert, Beate Eichelberger, Benjamin Panzer, Kurt Huber, Irene M. Lang, Renate Koppensteiner, Simon Panzer, Thomas Gremmel
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 3, Iss 3, Pp 383-390 (2019)
Abstract Background Despite the increasing use of potent P2Y12 inhibitors, further atherothrombotic events still impair the prognosis of many acute coronary syndrome (ACS) patients. This may in part be attributable to intact platelet aggregation via
Externí odkaz:
https://doaj.org/article/3965b7c84c154b3e9d2060d8edd75880