Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment.

Autor: Miciaccia, Morena¹ (AUTHOR) morena.miciaccia@uniba.it, Rizzo, Francesca² (AUTHOR) francesca.rizzo1@uniba.it, Centonze, Antonella¹ (AUTHOR) antonella.centonze1@uniba.it, Cavallaro, Gianfranco³ (AUTHOR) gianfranco.cavallaro@phd.unict.it, Contino, Marialessandra⁴ (AUTHOR) marialessandra.contino@uniba.it, Armenise, Domenico¹ (AUTHOR) domenico.armenise1@uniba.it, Baldelli, Olga Maria¹ (AUTHOR) olga.baldelli@uniba.it, Solidoro, Roberta¹ (AUTHOR) roberta.solidoro@uniba.it, Ferorelli, Savina¹ (AUTHOR) savina.ferorelli@uniba.it, Scarcia, Pasquale² (AUTHOR) pasquale.scarcia@uniba.it, Agrimi, Gennaro² (AUTHOR) gennaro.agrimi@uniba.it, Zingales, Veronica⁵ (AUTHOR) veronica.zingales@uv.es, Cimetta, Elisa⁵ (AUTHOR) elisa.cimetta@unipd.it, Ronsisvalle, Simone⁶ (AUTHOR) s.ronsisvalle@unict.it, Sipala, Federica Maria⁶ (AUTHOR) federica.sipala@phd.unict.it, Polosa, Paola Loguercio² (AUTHOR) paolaannamaria.loguerciopolosa@uniba.it, Fortuna, Cosimo Gianluca³ (AUTHOR) cg.fortuna@unict.it, Perrone, Maria Grazia¹ (AUTHOR) cg.fortuna@unict.it, Scilimati, Antonio¹ (AUTHOR) cg.fortuna@unict.it

Publikováno v: Pharmaceuticals (14248247). Jan2024, Vol. 17 Issue 1, p135. 17p.

Exploiting protease activation for therapy

Autor: Bleuez, Chloe, Koch, Wolfgang F., Urbach, Carole, Hollfelder, Florian, Jermutus, Lutz

Publikováno v: In Drug Discovery Today June 2022 27(6):1743-1754

Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture

Autor: Philipp Knyphausen, Mariana Rangel Pereira, Paul Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Custom proteases find applications as therapeutics, in research and in biotechnological applications. Here, the authors establish a protease selection system based on bacterial alpha-2-macroglobulin protease inhibitors and evolve staphylococcal prote

Externí odkaz: https://doaj.org/article/4a5f0a823f2043db90aef3f41550275c

Cytokine Suppression of Protease Activation in Wild-Type p53-Dependent and p53-Independent Apoptosis

Autor: Lotem, Joseph, Sachs, Leo

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1997 Aug . 94(17), 9349-9353.

Externí odkaz: https://www.jstor.org/stable/42607

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Autor: Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati

Publikováno v: Pharmaceuticals, Vol 17, Iss 1, p 135 (2024)

Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue. DIPG is the leading cause of death for pediatric brain tumors due to its infiltra

Externí odkaz: https://doaj.org/article/8511af1c24944524bc20ff6f3007c237