Zobrazeno 1 - 10
of 5 632
pro vyhledávání: '"protease‐activated receptor"'
Autor:
Yi-An Hsieh, Yi-Han Hsiao, Hsin-Kuo Ko, Yi-Luen Shen, Chien-Wen Huang, Diahn-Warng Perng, Kang-Cheng Su
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract House dust mites (HDM) are common aeroallergens linked to airway inflammation and remodeling in asthma. Protease-activated receptor 2 (PAR2) and thymic stromal lymphopoietin (TSLP) may mediate these immune responses. However, how the epithel
Externí odkaz:
https://doaj.org/article/4b83938d371645be85e3b0797899480b
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by chronic inflammation and progressive cartilage degradation, ultimately leading to joint dysfunction and disability. Oleocanthal (OC), a bioactive pheno
Externí odkaz:
https://doaj.org/article/de9571419ea74f33a3c2a66fe190a853
Autor:
Liam Emile Rondeau, Bruna Barbosa Da Luz, Alba Santiago, Miriam Bermudez-Brito, Amber Hann, Giada De Palma, Jennifer Jury, Xuanyu Wang, Elena Francisca Verdu, Heather Jean Galipeau, Corinne Rolland, Celine Deraison, Wolfram Ruf, Premysl Bercik, Nathalie Vergnolle, Alberto Caminero
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Imbalances in proteolytic activity have been linked to the development of inflammatory bowel diseases (IBD) and experimental colitis. Proteases in the intestine play important roles in maintaining homeostasis, but exposure of mucosal tissues to exces
Externí odkaz:
https://doaj.org/article/1bb25bf3ffc644a1b2fa596c3883f024
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Protease-activated receptor 2 (PAR2) is a cell-surface receptor expressed in various cell types, including keratinocytes, neurons, immune and inflammatory cells. Activation of PAR2, whether via its canonical or biased pathways, triggers a series of s
Externí odkaz:
https://doaj.org/article/200aed2213024bd9829e7b5d91f6d030
Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives
Autor:
Mengjie Fan, Xiaoyao Fan, Yangfan Lai, Jin Chen, Yifan Peng, Yao Peng, Leihong Xiang, Ying Ma
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Protease-activated receptor-2 (PAR2) is a class-A G protein-coupled receptor (GPCR) activated by serine proteases and is expressed by multiple tissues, including the skin. PAR2 is involved in the skin inflammatory response, promoting Th2 inflammation
Externí odkaz:
https://doaj.org/article/672beeb21db547d9af4f10458ca45108
Autor:
Xin Zhuo, Yue Wu, Xiujuan Fu, Jianbin Li, Yuxin Xiang, Xiaoyu Liang, Canquan Mao, Yuhong Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1441-1456 (2024)
Excessive and uncontrollable inflammatory responses in alveoli can dramatically exacerbate pulmonary disease progressions through vigorous cytokine releases, immune cell infiltration and protease-driven tissue damages. It is an urgent need to explore
Externí odkaz:
https://doaj.org/article/608b7220f53c431f91279a64cd355fcc
Autor:
Makoto Nakano, Satoshi Yasuda, Yuhi Hasebe, Kotaro Nochioka, Koji Fukuda, Jun Takahashi, Hiroaki Shimokawa
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 52, Iss , Pp 101387- (2024)
Externí odkaz:
https://doaj.org/article/f03fb9e07ebf4ea0a94d4fe9270e1dc5
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a 5-year survival rate of 6% following a diagnosis, and novel therapeutic modalities are needed. Protease-activated receptor 1 (PAR1) is abundantly overexpre
Externí odkaz:
https://doaj.org/article/c6596f5c0f934ffe888caea449003de4
Autor:
Ho Young Lee, Dorothy J. You, Alexia Taylor-Just, Logan J. Tisch, Ryan D. Bartone, Hannah M. Atkins, Lauren M. Ralph, Silvio Antoniak, James C. Bonner
Publikováno v:
Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) has been reported to exert strong pro-inflammatory and pro-fibrotic adjuvant effects in mouse models of allergic lung disease. However, the molecular mechanisms through
Externí odkaz:
https://doaj.org/article/32e1e4ddbe73477b8a60b356f6b92171
Autor:
Aurélie Hennes, Johanna Devroe, Katrien De Clercq, Martina Ciprietti, Katharina Held, Katrien Luyten, Nele Van Ranst, Nina Maenhoudt, Karen Peeraer, Hugo Vankelecom, Thomas Voets, Joris Vriens
Publikováno v:
Reproductive Biology and Endocrinology, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Early embryo implantation is a complex phenomenon characterized by the presence of an implantation-competent blastocyst and a receptive endometrium. Embryo development and endometrial receptivity must be synchronized and an adequa
Externí odkaz:
https://doaj.org/article/8fde655854e34d3da34d790977f972bf