Zobrazeno 1 - 10
of 312
pro vyhledávání: '"proscillaridin a"'
Autor:
Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Flores-Díaz, André Haman, Trang Hoang, Daniel Sinnett, Christian Beauséjour, Serge McGraw, Noël J.-M. Raynal
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identification of a specific c
Externí odkaz:
https://doaj.org/article/bdecc4d44be747e18ba1c9bfae4d8fcf
Akademický článek
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Autor:
Muhammad Zubair Saleem, Mohammed Alshwmi, He Zhang, Syed Riaz Ud Din, Muhammad Azhar Nisar, Muhammad Khan, Shahid Alam, Gulzar Alam, Lingling Jin, Tonghui Ma
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Breast cancer is the most heterogenous cancer type among women across the world. Despite concerted efforts, breast cancer management is still unsatisfactory. Interplay between apoptosis and autophagy is an imperative factor in categorizing therapeuti
Externí odkaz:
https://doaj.org/article/a18a76c0839242aea6cae02c705ee354
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 2, p 045 (2022)
Background: Urginea maritima (L.f.) Baker (Hyacinthaceae) is a perennial bulbous medicinal plant that is currently at risk of extinction. Squill (white sea onion) is an analogous cardiotonic to digitalis. The purpose of the current work was to assess
Externí odkaz:
https://doaj.org/article/6ea7f01217f640e9bfb206fc3b3595df
Akademický článek
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Publikováno v:
Research Journal of Pharmacognosy, Vol 3, Iss 3, Pp 1-7 (2016)
Background and objectives:Drimia maritima (L.) Stearn also known as squill is a medicinally important plant that has been used for various ailments such as dropsy, respiratory disorders, jaundice and epilepsy from ancient times. Proscillaridin A is i
Externí odkaz:
https://doaj.org/article/8a27beecc1154b3eb8eeb39be3dc3217
Autor:
Marielle Huot, Chantal Richer, Rahinatou Djibo, Rafael Najmanovich, Daniel Sinnett, Noël J.-M. Raynal, Maxime Caron, Pascal St-Onge
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:845-856
Embryonal rhabdomyosarcoma (eRMS) is the most common type of rhabdomyosarcoma in children. eRMS is characterized by malignant skeletal muscle cells driven by hyperactivation of several oncogenic pathways including the MYC pathway. Targeting MYC in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd098507a54b5609f9989cfc5a2f77e
https://doi.org/10.1007/s00280-021-04339-6
https://doi.org/10.1007/s00280-021-04339-6
Publikováno v:
Molecules; Volume 27; Issue 18; Pages: 5988
The SARS-CoV-2 targets were evaluated for a set of FDA-approved drugs using a combination of drug repositioning and rigorous computational modeling methodologies such as molecular docking and molecular dynamics (MD) simulations followed by binding fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b9a5500c5e93e9a2b877f4cd7a9e9d
https://pubmed.ncbi.nlm.nih.gov/36144718
https://pubmed.ncbi.nlm.nih.gov/36144718
Autor:
Manami Semba, Shinji Takamatsu, Sachiko Komazawa-Sakon, Eiji Miyoshi, Chiharu Nishiyama, Hiroyasu Nakano, Kenta Moriwaki
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 6973
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytotoxic cytokine that induces cancer cell death by binding to TRAIL receptors. Because of its selective cytotoxicity toward cancer cells, TRAIL therapeutics, such as recombinant T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780cd48c7d0473806adebcfc9b9fbe79
https://pubmed.ncbi.nlm.nih.gov/35805980
https://pubmed.ncbi.nlm.nih.gov/35805980
Akademický článek
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