Zobrazeno 1 - 10
of 342
pro vyhledávání: '"proprotein convertase subtilisin-kexin type 9 (PCSK9)"'
Autor:
Ping Lai, Shuquan Xu, Ziyou Liu, Jiayuan Ling, Kejun Tian, Jianwei Yan, Dong Chen, Yiming Zhong, Jinhua Xue
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundFollowing the identification of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, research in this area has experienced significant growth. However, a thorough bibliometric analysis of this burgeoning field remains conspicuo
Externí odkaz:
https://doaj.org/article/e9e7e988e3a34a8daec9427a1dafbeba
Autor:
Frans B. Mensink, Jonathan Los, Rohit M. Oemrawsingh, Clemens von Birgelen, Alexander Ijsselmuiden, Martijn Meuwissen, Jin M. Cheng, Diederik F. van Wijk, Pieter C. Smits, Valeria Paradies, Dirk J. van der Heijden, Himanshu Rai, Tim JF. ten Cate, Cyril Camaro, Peter Damman, Lokien X. van Nunen, Aukelien C. Dimitriu-Leen, Marleen H. van Wely, Aysun Cetinyurek-Yavuz, Robert A. Byrne, Niels van Royen, Robert-Jan M. van Geuns
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38077- (2024)
Non-culprit coronary artery lesions are commonly present in patients presenting with an acute coronary syndrome (ACS). Additional stenting of non-culprit lesions in addition to the culprit lesion intends to prevent secondary events caused by these le
Externí odkaz:
https://doaj.org/article/b41e72e1265843fb8be2ceed88f6426d
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Melanoma proliferation is partly attributed to dysregulated lipid metabolism. The effectiveness of lipid-lowering drugs in combating cutaneous melanoma (CM) is a subject of ongoing debate in both in vitro and clinical studies. Met
Externí odkaz:
https://doaj.org/article/525964663de24daf8fe030b98848ab0a
Autor:
Khursheed Muzammil, Mohammad Hosseini Hooshiar, Shirin Varmazyar, Thabit Moath Omar, Manal Morad Karim, Sadeq Aadi, Shaylan Kalavi, Saman Yasamineh
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-22 (2024)
Abstract Cellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize lipids as viral receptors. Viruses depend signi
Externí odkaz:
https://doaj.org/article/4a6f0dca0f2b4e3f93039385058e11d9
Autor:
Milan Gupta, Rajvi J. Wani, Khalid Al Faraidy, Jean Bergeron, Eduardo Contreras, Angel Alberto Garcia Peña, G. B. John Mancini, Francisco Padilla, Abel Alberto Pavia Lopez, Kiran Philip, Johnny Wu, Erin S. Mackinnon
Publikováno v:
Cardiology and Therapy, Vol 12, Iss 4, Pp 703-722 (2023)
Abstract Introduction This study characterizes patients receiving evolocumab in clinical practice and assesses treatment effectiveness, safety and persistence outcomes across five countries. Methods This retrospective and prospective observational st
Externí odkaz:
https://doaj.org/article/871e335605904a328cdc04840034dac7
Publikováno v:
Рациональная фармакотерапия в кардиологии, Vol 19, Iss 2, Pp 143-150 (2023)
Aim. To study the frequency of prescriptions of various types of lipid-lowering therapy and their effectiveness in outpatient clinical practice based on the results of a questionnaire of primary care physicians.Material and methods. The study was per
Externí odkaz:
https://doaj.org/article/37d179a1ea3a412c8ae7ca9c442b1d30
Autor:
Lawrence A. Leiter, Robert A. Hegele, Vivien Brown, Jean Bergeron, Erin S. Mackinnon, G. B. John Mancini
Publikováno v:
Reviews in Cardiovascular Medicine, Vol 25, Iss 5, p 190 (2024)
Elevated low-density lipoprotein cholesterol (LDL-C) is a major causal factor for atherosclerotic cardiovascular disease (ASCVD), the leading cause of mortality worldwide. Statins are the recommended first-line lipid-lowering therapy (LLT) for patien
Externí odkaz:
https://doaj.org/article/7d37757b25cc40d5b67d09e98b0d1b2e
Autor:
Jun Sawaguchi, Yasuhiko Saeki, Minako Oda, Taka-aki Takamura, Kosuke Fujibayashi, Minoru Wakasa, Hironobu Akao, Michihiko Kitayama, Yasuyuki Kawai, Kouji Kajinami
Publikováno v:
Atherosclerosis Plus, Vol 50, Iss , Pp 50-56 (2022)
Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulates as mature and furin-cleaved forms, but their biological functions are uncertain. We investigated whether their levels associate with prognosis in patients with acut
Externí odkaz:
https://doaj.org/article/8be69b50c8eb40c3b86ad57041cf6cf0
Autor:
Bowen Lou, Hui Liu, Yongbai Luo, Gulinigaer Tuerhong Jiang, Haoyu Wu, Chen Wang, Yue Wu, Bo Zhou, Zuyi Yuan, Jianqing She, Junhui Liu
Publikováno v:
Lipids in Health and Disease, Vol 21, Iss 1, Pp 1-12 (2022)
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been shown to improve cardiovascular outcomes when added to conventional statin therapy. This study aims to investigate the efficacy and safety of in-hospital i
Externí odkaz:
https://doaj.org/article/a4aaa7da2c604ed9bd5ae58218c15f9e
Autor:
Alicja Braczko, Gabriela Harasim, Ada Kawecka, Iga Walczak, Małgorzata Kapusta, Magdalena Narajczyk, Klaudia Stawarska, Ryszard T. Smoleński, Barbara Kutryb-Zając
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: Statins and proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are cornerstones of therapy to prevent cardiovascular disease, acting by lowering lipid concentrations and only partially identified pleiotropic effects. This s
Externí odkaz:
https://doaj.org/article/f4e70ca59ea24d348eb8ab297afb9518