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of 430
pro vyhledávání: '"prongf"'
Autor:
Marie Anne Makoudjou, Elena Fico, Pamela Rosso, Viviana Triaca, Lucio De Simone, Daniela Rossetti, Franca Cattani, Marcello Allegretti, Paola Tirassa
Publikováno v:
FEBS Open Bio, Vol 14, Iss 4, Pp 643-654 (2024)
The neurotrophin nerve growth factor (NGF) and its precursor proNGF are both bioactive and exert similar or opposite actions depending on the cell target and its milieu. The balance between NGF and proNGF is crucial for cell and tissue homeostasis an
Externí odkaz:
https://doaj.org/article/b0ab1350e18643218da57bfbfb5c3708
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101702- (2024)
ProNGF (nerve growth factor) is a precursor of NGF and a signaling peptide exerting opposite effects on neuronal cells, i.e., apoptotic or neuritogenic. The conflicting biological activity of proNGF depends on the relative levels of two membrane rece
Externí odkaz:
https://doaj.org/article/7e766c5b0f2c4b238e12f38f7eff565d
Autor:
Julien Cicero, Sarah Trouvilliez, Martine Palma, Gaetan Ternier, Laurine Decoster, Eloise Happernegg, Nicolas Barois, Alexandre Van Outryve, Lucie Dehouck, Roland P. Bourette, Eric Adriaenssens, Chann Lagadec, Cagatay Mehmet Tarhan, Dominique Collard, Zied Souguir, Elodie Vandenhaute, Grégory Maubon, François Sipieter, Nicolas Borghi, Fumitaka Shimizu, Takashi Kanda, Paolo Giacobini, Fabien Gosselet, Nathalie Maubon, Xuefen Le Bourhis, Isabelle Van Seuningen, Caroline Mysiorek, Robert-Alain Toillon
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-20 (2023)
Abstract Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition to reducing survival. The development of brain metastases i
Externí odkaz:
https://doaj.org/article/a669d848d8994ea18bb634e2c30e3e37
Autor:
George N. Chaldakov, Luigi Aloe, Stanislav G. Yanev, Marco Fiore, Anton B. Tonchev, Manlio Vinciguerra, Nikolai T. Evtimov, Peter Ghenev, Krikor Dikranian
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 961 (2024)
Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases. The following pressing question thus remains: what are
Externí odkaz:
https://doaj.org/article/e528d37e1f31482dafc8ff3f416bb83d
Autor:
Francesca Malerba, Rita Florio, Ivan Arisi, Chiara Zecca, Maria Teresa Dell’Abate, Giancarlo Logroscino, Antonino Cattaneo
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2024)
IntroductionFrontotemporal dementia (FTD) is an extremely heterogeneous and complex neurodegenerative disease, exhibiting different phenotypes, genetic backgrounds, and pathological states. Due to these characteristics, and to the fact that clinical
Externí odkaz:
https://doaj.org/article/a24619c53d5c4edca209e684e795b7a1
Akademický článek
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Akademický článek
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Autor:
Gemma Eftimiadi, Marzia Soligo, Luigi Manni, Daniela Di Giuda, Maria Lucia Calcagni, Antonio Chiaretti
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 9, Pp 1740-1750 (2021)
Neurotrophins are a family of proteins that support neuronal proliferation, survival, and differentiation in the central and peripheral nervous systems, and are regulators of neuronal plasticity. Nerve growth factor is one of the best-described neuro
Externí odkaz:
https://doaj.org/article/74f14db3775e4fcf9fce61f1b5d72aed
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 11, Pp 1448-1461 (2020)
Abstract Severe conjunctival diseases can cause significant conjunctival scarring, which seriously limits eye movement and affects patients' vision. Conjunctival reconstruction remains challenging due to the lack of efficient methods for stem cells e
Externí odkaz:
https://doaj.org/article/de4b25dd56334ffd822cdccd51698d96
Autor:
Sam Faulkner, Nathan Griffin, Christopher W. Rowe, Phillip Jobling, Janine M. Lombard, Sonia M. Oliveira, Marjorie M. Walker, Hubert Hondermarck
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 7, Pp 398-408 (2020)
Abstract Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF
Externí odkaz:
https://doaj.org/article/c993e07b2b364f0ea4cb27aaf9d18bbb