Zobrazeno 1 - 10
of 8 867
pro vyhledávání: '"promoter methylation"'
Publikováno v:
Chinese Neurosurgical Journal, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background High-grade gliomas (HGGs) have a rapid relapse and short survival. Studies have identified many clinical characteristics and biomarkers associated with progression-free survival (PFS) and over-survival (OS). However, there has not
Externí odkaz:
https://doaj.org/article/8ea26f276456430cb4e65dd820a2e957
Autor:
Konrad Grützmann, Theresa Kraft, Matthias Meinhardt, Friedegund Meier, Dana Westphal, Michael Seifert
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1036-1050 (2024)
Melanoma, the deadliest form of skin cancer, can metastasize to different organs. Molecular differences between brain and extracranial melanoma metastases are poorly understood. Here, promoter methylation and gene expression of 11 heterogeneous patie
Externí odkaz:
https://doaj.org/article/22878d96341a4e81866b8b51ae880f20
Autor:
Hatim Boughanem, Jesús pilo, Libia Alejandra García-Flores, Isabel Arranz, María Ramos-Fernandez, María Ortega-Castan, Ana B. Crujeiras, Juan Sandoval, Manuel Macias-Gonzalez
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Several studies have suggested secreted frizzled-related protein 2 (SFRP2) gene as a potential clinical biomarker in colorectal cancer (CRC). However, its diagnostic role remains unclear. In this study, we aimed to investigate the
Externí odkaz:
https://doaj.org/article/e96d485c5b1a4387a7d66a129aa3304b
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 4, Pp 335-347 (2024)
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease, and the role of HOXA transcript at the distal tip (HOTTIP) in its pathogenesis remains underexplored. This study investigates the mechanism by which HOTTIP influences ap
Externí odkaz:
https://doaj.org/article/b5e81d94be1a4f7cbbe016f3427d5a55
Autor:
Xianhao Huo, Haoyuan Li, Yixiang Xing, Wenqing Liu, Pengfei Chen, Fang Du, Lijuan Song, Zhenhua Yu, Xiangmei Cao, Jihui Tian
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
AimsThis study aims to systematically analyze the global trends in glioma methylation research using bibliometric methodologies. We focus on identifying the scholarly trajectory and key research interests, and we utilize these insights to predict fut
Externí odkaz:
https://doaj.org/article/f36dfffa180a43af818fb920a83fa179
Publikováno v:
BMC Medical Imaging, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Traditional process for clinically significant prostate cancer (csPCA) diagnosis relies on invasive biopsy and may bring pain and complications. Radiomic features of magnetic resonance imaging MRI and methylation of the PRKY promo
Externí odkaz:
https://doaj.org/article/cfe665ba6f02484db56505a8113711cd
Autor:
Anja Kafka, Nives Pećina-Šlaus, Denis Drmić, Anja Bukovac, Niko Njirić, Kamelija Žarković, Antonia Jakovčević
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionEpigenetics play a vital role in stratifying CNS tumors and gliomas. The importance of studying Secreted frizzled-related protein 4 (SFRP4) in gliomas is to improve diffuse glioma methylation profiling. Here we examined the methylation st
Externí odkaz:
https://doaj.org/article/0d72b10c58e248758d2f257d6be37a4e
Publikováno v:
Poultry Science, Vol 103, Iss 5, Pp 103559- (2024)
ABSTRACT: Peroxisome proliferator-activated receptor gamma (PPARγ) is a master regulator of adipogenesis. Our previous study revealed that chicken PPARγ has 3 alternative promoters named as P1, P2, and P3, and the DNA methylation of promoter P3 was
Externí odkaz:
https://doaj.org/article/fc7b2adef2f04856ba6d3e652af3a30f
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-13 (2023)
Abstract Aims Diabetic cardiomyopathy (DCM) is a major complication of diabetes and a risk factor for cardiovascular disease. Endothelial dysfunction is central to DCM, and endothelial-to-mesenchymal transition (EndMT) is a key form of endothelial dy
Externí odkaz:
https://doaj.org/article/9cf1413b293c47ea9593f0824e641316
Autor:
Yutaro Hara, Hiroki Mizukami, Keisuke Yamazaki, Takahiro Yamada, Akiko Igawa, Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Kotaro Murakami, Kazuhiro Kudoh, Keinosuke Ishido, Kenichi Hakamada
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 5, Pp 354-366 (2023)
Abstract Diabetes mellitus (DM) is a risk factor for pancreatic ductal adenocarcinoma (PDAC) that promotes the promoter methylation of CDH1. It is still unclear whether DM can exert other epigenetic effects, such as altering microRNA (miR) expression
Externí odkaz:
https://doaj.org/article/49220e3a8e094148a1c67db469d803bb