Decrease of Prolylcarboxypeptidase Dose of Aqueous Humor is Involved in the Pathogenesis of Primary Open-Angle Glaucoma via Finetuning of the Local Ocular Renin-Angiotensin System.

Autor: Ren, Jing¹ (AUTHOR), Xiao, Yuanyuan¹ (AUTHOR), Wang, Di¹ (AUTHOR), Cui, Huiling¹ (AUTHOR), Zhao, Rumeng¹ (AUTHOR), Guo, Zilu¹ (AUTHOR), Wang, Yuhao² (AUTHOR), Zhu, Shichao³ (AUTHOR), Tang, Bo⁴ (AUTHOR), Wang, Jing⁵ (AUTHOR), Wang, Gang¹ (AUTHOR), Wang, Huaying⁵ (AUTHOR), Hu, Xinyuan⁵ (AUTHOR), Thorne, Rick F.⁵ (AUTHOR) lihaijun@zzu.edu.cn, Duan, Shichao¹ (AUTHOR) lihaijun@zzu.edu.cn, Li, Haijun¹ (AUTHOR) lihaijun@zzu.edu.cn

Publikováno v: Dose-Response. Oct-Dec2024, Vol. 22 Issue 4, p1-14. 14p.

Clinical Relevance of Plasma Prolylcarboxypeptidase Level in Patients with Idiopathic Acute Optic Neuritis.

Autor: Kim, Jong-Heon¹ (AUTHOR) jongheonkim.phd@gmail.com, Shin, Dae Beom² (AUTHOR), Suk, Kyoungho^1,3 (AUTHOR) ksuk@knu.ac.kr, Chun, Bo Young^1,2 (AUTHOR) byjun424@hotmail.com

Publikováno v: Journal of Clinical Medicine. Apr2024, Vol. 13 Issue 7, p2038. 11p.

C1 inhibitor and prolylcarboxypeptidase modulate prekallikrein activation on endothelial cells

Autor: Merkulova, Alona A., Abdalian, Sarah, Silbak, Sadiq, Pinheiro, Alessandro, Schmaier, Alvin H.

Publikováno v: In The Journal of Allergy and Clinical Immunology October 2023 152(4):961-971

Increased Prolylcarboxypeptidase Expression Can Serve as a Biomarker of Senescence in Culture

Autor: Nicholas Glen Boullard, Jason J. Paris, Zia Shariat-Madar, Fakhri Mahdi

Publikováno v: Molecules, Vol 29, Iss 10, p 2219 (2024)

Prolylcarboxypeptidase (PRCP, PCP, Lysosomal Pro-X-carboxypeptidase, Angiotensinase C) controls angiotensin- and kinin-induced cell signaling. Elevation of PRCP appears to be activated in chronic inflammatory diseases [cardiovascular disease (CVD), d

Externí odkaz: https://doaj.org/article/b74d598d5b8a44829589c111cff8df25

Prolylcarboxypeptidase promotes IGF1R/HER3 signaling and is a potential target to improve endocrine therapy response in estrogen receptor positive breast cancer

Autor: Lei Duan, Sarah J. Calhoun, Ricardo E. Perez, Virgilia Macias, Fatima Mir, Paolo Gattuso, Carl G. Maki

Publikováno v: Cancer Biology & Therapy, Vol 23, Iss 1, Pp 1-10 (2022)

Prolylcarboxypeptidase (PRCP) is a lysosomal serine protease that cleaves peptide substrates when the penultimate amino acid is proline. Previous studies have linked PRCP to blood-pressure and appetite control through its ability to cleave peptide su

Externí odkaz: https://doaj.org/article/e0b21a7db1594ba68016162e3dbd013c