Zobrazeno 1 - 10
of 173
pro vyhledávání: '"prolyl trna synthetase"'
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 4, Pp 348-359 (2024)
Abstract The effects of evodiamine (EVO) on oral squamous cell carcinoma (OSCC) are not yet understood. Based on our earlier findings, we hypothesized that evodiamine may affect OSCC cell proliferation and glutamate metabolism by modulating the expre
Externí odkaz:
https://doaj.org/article/43f14f31f876482ea425f7d4bc504af7
Autor:
Dong-Keon Lee, Su Ho Jo, Eun Soo Lee, Kyung Bong Ha, Na Won Park, Deok-Hoon Kong, Sang-In Park, Joon Seok Park, Choon Hee Chung
Publikováno v:
Diabetes & Metabolism Journal, Vol 48, Iss 1, Pp 97-111 (2024)
Background Nonalcoholic steatohepatitis (NASH) is a liver disease caused by obesity that leads to hepatic lipoapoptosis, resulting in fibrosis and cirrhosis. However, the mechanism underlying NASH is largely unknown, and there is currently no effecti
Externí odkaz:
https://doaj.org/article/4e05d3a61b37453fa255535f97cd6392
Autor:
Ina Yoon, Sulhee Kim, Minjae Cho, Kyung Ah You, Jonghyeon Son, Caroline Lee, Ji Hun Suh, Da‐Jeong Bae, Jong Min Kim, Sinae Oh, Songhwa Park, Sanga Kim, Seong Hyeok Cho, Seonha Park, Kyuhyeon Bang, Minjeong Seo, Jong Hyun Kim, Bongyong Lee, Joon Seok Park, Kwang Yeon Hwang, Sunghoon Kim
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 7, Pp 1-21 (2023)
Abstract Prolyl‐tRNA synthetase 1 (PARS1) has attracted much interest in controlling pathologic accumulation of collagen containing high amounts of proline in fibrotic diseases. However, there are concerns about its catalytic inhibition for potenti
Externí odkaz:
https://doaj.org/article/c423ef5903cf4af4baee1d3b57474eab
Publikováno v:
Infectious Agents and Cancer, Vol 18, Iss 1, Pp 1-10 (2023)
Abstract Background Glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is an aminoacyl-tRNA synthase involved in the pathology of cancer and other diseases. In this study, we investigated the carcinogenic function, potential mechanism, and clinical significan
Externí odkaz:
https://doaj.org/article/68157eb692ac4933877ef36ea9ebe943
Autor:
Abdurraouf Abaya, Geovanna Cristina Zaro, Alvaro De la Mora Pena, Tom Hsiang, Paul H. Goodwin
Publikováno v:
Plants, Vol 13, Iss 2, p 300 (2024)
American ginseng (Panax quinquefolius) is widely used due to its medicinal properties. Ontario is a major producer of cultivated American ginseng, where seeds were originally collected from the wild without any subsequent scientific selection, and th
Externí odkaz:
https://doaj.org/article/d00021c529f74396988584b6ba16a0ad
Akademický článek
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Publikováno v:
Viruses, Vol 15, Iss 2, p 474 (2023)
Host factor tRNAs facilitate the replication of retroviruses such as human immunodeficiency virus type 1 (HIV-1). HIV-1 uses human tRNALys3 as the primer for reverse transcription, and the assembly of HIV-1 structural protein Gag at the plasma membra
Externí odkaz:
https://doaj.org/article/b5891c381b9f4cb7a210349f98c6dc9b
Publikováno v:
IUCrJ, Vol 6, Iss 5, Pp 958-967 (2019)
Aminoacyl-tRNA synthetases (ARSs) play essential roles in protein biosynthesis as well as in other cellular processes, often using evolutionarily acquired domains. For possible cooperativity and synergistic effects, nine ARSs assemble into the multi-
Externí odkaz:
https://doaj.org/article/6bdecdfa4b7b4e75a28d5096ab7f0cb0
Autor:
Vinod Sukanth Kumar Pallabothula, Marek Kerda, Martin Juhás, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Pavla Paterová, Jan Zitko
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1561 (2022)
Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such earned its place on the WHO list of priority pathogens. New antimycobacterials with a mechanism of action different to currently used agents are highly requir
Externí odkaz:
https://doaj.org/article/8407d76be4d84611821259c8a5fa6dd2
Akademický článek
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