In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1

Autor: Christensen, Emily M., Bogner, Alexandra N., Vandekeere, Anke, Tam, Gabriela S., Patel, Sagar M., Becker, Donald F., Fendt, Sarah-Maria, Tanner, John J. ^*

Publikováno v: In Journal of Biological Chemistry 25 December 2020 295(52):18316-18327

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The proline cycle as a eukaryotic redox valve

Autor: Séverine Planchais, Arnould Savouré, Yao Zheng, Sandrine Lebreton, Cécile Cabassa-Hourton

Publikováno v: Journal of Experimental Botany
Journal of Experimental Botany, Oxford University Press (OUP), 2021, ⟨10.1093/jxb/erab361⟩
Journal of Experimental Botany, 2021, 72 (20), pp.6856-6866. ⟨10.1093/jxb/erab361⟩

The amino acid proline has been known for many years to be a component of proteins as well as an osmolyte. Many recent studies have demonstrated that proline has other roles such as regulating redox balance and energy status. In animals and plants, t

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https://hal.sorbonne-universite.fr/hal-03360252/document

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In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1

Autor: John J. Tanner, Gabriela S. Tam, Anke Vandekeere, Alexandra N. Bogner, Sagar M. Patel, Emily M. Christensen, Donald F. Becker, Sarah-Maria Fendt

Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry

Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d1f0867fe7a0a3900fc23d93d6e2a4
https://doi.org/10.1074/jbc.ra120.016106