Výsledky vyhledávání - "processivity"

Akademický článek

The cellular paraspeckle component SFPQ associates with the viral processivity factor ORF59 during lytic replication of Kaposi's Sarcoma-associated herpesvirus (KSHV)

Autor: Shannon Harger Payen, Kayla Andrada, Evelyn Tara, Juli Petereit, Subhash C. Verma, Cyprian C. Rossetto

Publikováno v: Virus Research, Vol 349, Iss , Pp 199456- (2024)

Kaposi's sarcoma-associated herpesvirus (KSHV) relies on many cellular proteins to complete replication and generate new virions. Paraspeckle nuclear bodies consisting of core ribonucleoproteins splicing factor proline/glutamine-rich (SFPQ), Non-POU

Externí odkaz: https://doaj.org/article/31ed2f57b79440feae0b81ae6c02ab9b

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Akademický článek

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Akademický článek

Structural and functional snapshots of a broad-specificity endoglucanase from Thermogutta terrifontis for biomass saccharification

Autor: Hussain, Naveed ^{a, b, c, d, e}, Mikolajek, Halina ^{c, f}, Harrison, Peter J. ^{b, c, f}, Paterson, Neil ^f, Akhtar, Muhammad W. ^{a, e, ⁎}, Sadaf, Saima ^{a, ⁎⁎}, Naismith, James H. ^{b, d, ⁎⁎⁎}

Publikováno v: In Archives of Biochemistry and Biophysics February 2025 764

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Akademický článek

MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma

Autor: Consuelo Pitolli, Alberto Marini, Marika Guerra, Marco Pieraccioli, Veronica Marabitti, Fernando Palluzzi, Luciano Giacò, Gianpiero Tamburrini, Francesco Cecconi, Francesca Nazio, Claudio Sette, Vittoria Pagliarini

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)

Abstract Background Medulloblastoma (MB) is the most common cerebellar malignancy during childhood. Among MB, MYC-amplified Group 3 tumors display the worst prognosis. MYC is an oncogenic transcription factor currently thought to be undruggable. Neve

Externí odkaz: https://doaj.org/article/030743204b074a1299f471eeca329a4b

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Akademický článek

Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues

Autor: Kyle R. Smith, Somnath Paul, Qiwen Dong, Orchi Anannya, Darby G. Oldenburg, J. Craig Forrest, Kevin M. McBride, Laurie T. Krug

Publikováno v: mSphere, Vol 8, Iss 5 (2023)

ABSTRACT Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from

Externí odkaz: https://doaj.org/article/db2ec48fefc6463ba061614bbbfb2d73

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Akademický článek

Bst polymerase — a humble relative of Taq polymerase

Autor: Igor Oscorbin, Maxim Filipenko

Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4519-4535 (2023)

DNA polymerases are a superfamily of enzymes synthesizing DNA using DNA as a template. They are essential for nucleic acid metabolism and for DNA replication and repair. Modern biotechnology and molecular diagnostics rely heavily on DNA polymerases i

Externí odkaz: https://doaj.org/article/cc20e28c2c264a469e766effbd0a83c8

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