Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed tablets using NIR spectroscopy

Autor: Sarah J. Trenfield, Xiaoyan Xu, Alvaro Goyanes, Martin Rowland, David Wilsdon, Simon Gaisford, Abdul W. Basit

Publikováno v: International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100148- (2023)

Selective laser sintering (SLS) 3D printing is a revolutionary 3D printing technology that has been found capable of creating drug products with varied release profiles by changing the laser scanning speed. Here, SLS 3D printed formulations (printlet

Externí odkaz: https://doaj.org/article/96cbf68dc2594824a6a65322448a8b7d

At-Line Reversed Phase Liquid Chromatography for In-Process Monitoring of Inclusion Body Solubilization

Autor: Julian Ebner, Diana Humer, Robert Klausser, Viktor Rubus, Reinhard Pell, Oliver Spadiut, Julian Kopp

Publikováno v: Bioengineering, Vol 8, Iss 6, p 78 (2021)

Refolding is known as the bottleneck in inclusion body (IB) downstream processing in the pharmaceutical industry: high dilutions leading to large operating volumes, slow refolding kinetics and low refolding yields are only a few of the problems that

Externí odkaz: https://doaj.org/article/13804829808243b9a7d88d961c13c66e

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed tablets using NIR spectroscopy.

Autor: Trenfield SJ; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK., Xu X; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK., Goyanes A; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.; Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R + D Pharma Group (GI-1645), Universidade de Santiago de Compostela, 15782, Spain., Rowland M; Pfizer Ltd., Drug Product Design, Discovery Park, Ramsgate Road, Sandwich CT13 9ND, UK., Wilsdon D; Pfizer Ltd., 280 Shennecossett Road, Groton, CT 06340, United States., Gaisford S; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK., Basit AW; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.

Publikováno v: International journal of pharmaceutics: X [Int J Pharm X] 2022 Dec 17; Vol. 5, pp. 100148. Date of Electronic Publication: 2022 Dec 17 (Print Publication: 2023).