Zobrazeno 1 - 10
of 5 097
pro vyhledávání: '"process analytical technology"'
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Secreted metabolites are an important class of bio‐process analytical technology (PAT) targets that can correlate to cell conditions. However, current strategies for measuring metabolites are limited to discrete measurements, resulting in
Externí odkaz:
https://doaj.org/article/bcd4874932c54376b1c73621ef4f4803
Autor:
Yash Barhate, Christopher Boyle, Hossein Salami, Wei-Lee Wu, Nina Taherimakhsousi, Charlie Rabinowitz, Andreas Bommarius, Javier Cardona, Zoltan K. Nagy, Ronald Rousseau, Martha Grover
Publikováno v:
Digital Chemical Engineering, Vol 11, Iss , Pp 100150- (2024)
Imaging and image-based process analytical technologies (PAT) have revolutionized the design, development, and operation of crystallization processes, providing greater process understanding through the characterization of particle size, shape and cr
Externí odkaz:
https://doaj.org/article/2e25512e68fd4032861d3642c99a7705
Autor:
Simona Dzurendova, Pernille Margrethe Olsen, Dana Byrtusová, Valeria Tafintseva, Volha Shapaval, Svein Jarle Horn, Achim Kohler, Martin Szotkowski, Ivana Marova, Boris Zimmermann
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background Monitoring and control of both growth media and microbial biomass is extremely important for the development of economical bioprocesses. Unfortunately, process monitoring is still dependent on a limited number of standard paramete
Externí odkaz:
https://doaj.org/article/a4df62c932b64254989cfdbabcfc65cd
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Pharmaceutical manufacturing is reliant upon bioprocessing approaches to generate the range of therapeutic products that are available today. The high cost of production, susceptibility to process failure, and requirement to achieve consistent, high-
Externí odkaz:
https://doaj.org/article/556b9f91ead44dcd9f0349d187fa84c1
Autor:
Christina Henriette Wegner, Sebastian Mathis Eming, Brigitte Walla, Daniel Bischoff, Dirk Weuster-Botz, Jürgen Hubbuch
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Protein crystallization as opposed to well-established chromatography processes has the benefits to reduce production costs while reaching a comparable high purity. However, monitoring crystallization processes remains a challenge as the produced cry
Externí odkaz:
https://doaj.org/article/fa4a1b828ff5499aa3726e5163379ec0
Akademický článek
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Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Chemometric modeling for spectral data is considered a key technology in biopharmaceutical processing to realize real-time process control and release testing. Machine learning (ML) models have been shown to increase the accuracy of various spectral
Externí odkaz:
https://doaj.org/article/1d6deebc14b142d98d4769d585f3ad23
Autor:
Prince Bawuah, Mike Evans, Ard Lura, Daniel J. Farrell, Patrick J. Barrie, Peter Kleinebudde, Daniel Markl, J. Axel Zeitler
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100186- (2023)
Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets and commer
Externí odkaz:
https://doaj.org/article/8f9989308d494dcf80b7a71bb5279f75
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe implementation of process analytical technologies is positioned to play a critical role in advancing biopharmaceutical manufacturing by simultaneously resolving clinical, regulatory, and cost challenges. Raman spectroscopy is emerging as
Externí odkaz:
https://doaj.org/article/0161eea1d0594364a4824a14f85c1de0