A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency

Autor: R. Campbell Tait, Sarah K Westbury, Dirk Hendriks, Kate Downes, Claire S. Whyte, Andrew D Mumford, Nicola J. Mutch, Jonathan Stephens, Karen Claesen, Nihr BioResource, Ernest Turro, Joachim C. Mertens, Emma J Leishman, Anne-Louise Latif

Publikováno v: Westbury, S K, Whyte, C S, Stephens, J, Downes, K, Turro, E, Claesen, K, Mertens, J, Hendriks, D, Latif, A-L, Leishman, E, Mutch, N J & Tait, C R & Mumford, A D 2020, ' A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency ', Journal of Thrombosis and Haemostasis . https://doi.org/10.1111/jth.14990
Journal of thrombosis and haemostasis

Background: Thrombomodulin-associated coagulopathy (TM-AC) is a rare bleeding disorder in which a single reported p.Cys537* variant in the thrombomodulin gene THBD causes high plasma thrombomodulin (TM) levels. High TM levels attenuate thrombin gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c157a370d0e881f53aa770a2ad3679b4
https://research-information.bris.ac.uk/en/publications/6789ca66-5e8d-46c1-99cc-29e55d539469

Inhibition of the procarboxypeptidase U (proCPU, TAFI, proCPB2) system due to hemolysis

Autor: Dirk Hendriks, Karen Claesen, Anne-Marie Lambeir, Joachim C. Mertens, Yani Sim, Dorien Leenaerts

Publikováno v: Journal of thrombosis and haemostasis

Essentials Hemolytic influence on the (pro)carboxypeptidase U ((pro)CPU) system is not known. In the current manuscript, this was assessed by spiking pooled normal plasma with hemolysate. CPU activity, proCPU levels, and clot lysis times showed a dos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add6f55952d4fbcaa1ab6ce4e61d71ab
https://hdl.handle.net/10067/1598100151162165141

The decrease in procarboxypeptidase U (TAFI) concentration in acute ischemic stroke correlates with stroke severity, evolution and outcome

Autor: Dirk Hendriks, D. de Surgeloose, Rishi Sheorajpanday, Raf Brouns, J. L. Willemse, P.P. De Deyn, Evelien Heylen, Robert Verkerk

Publikováno v: Vrije Universiteit Brussel
Journal of thrombosis and haemostasis

See also Willemse JL, Brouns R, Heylen E, De Deyn PP, Hendriks DF. Carboxypeptidase U (TAFIa) activity is induced in vivo in ischemic stroke patients receiving thrombolytic therapy. J Thromb Haemost 2008; 6: 200–2. Summary. Background and objective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300db891a3a216e9e784b22e51cfa1a1
https://doi.org/10.1111/j.1538-7836.2009.03663.x

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LETTERS TO THE EDITOR: Fast kinetic assay for the determination of procarboxypeptidase U (TAFI) in human plasma

Autor: J. L. Willemse, Judith Leurs, Dirk Hendriks

Publikováno v: Journal of Thrombosis and Haemostasis. 3:2353-2355

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd1fe72a410ee2b4d304e6ca3d32b5b5
https://doi.org/10.1111/j.1538-7836.2005.01558.x