Case report: An autopsy case of pilsicainide poisoning

Autor: Sella Takei, Hiroshi Kinoshita, Mitsuru Kumihashi, Mostofa Jamal, Hiroko Abe, Shoji Kimura

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

We present a fatal case of pilsicainide poisoning. Quantitative toxicological analysis revealed that the concentrations of pilsicainide in femoral blood and urine samples were 17.5 μg/mL and 136.9 μg/mL, respectively. No morphological changes due t

Externí odkaz: https://doaj.org/article/05ec86395c7b4962a9d781828f09eba9

Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk

Autor: Nathalie Nguyen, William Nguyen, Brynna Nguyenton, Phachareeya Ratchada, Guy Page, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges

Publikováno v: Frontiers in Physiology, Vol 8 (2017)

Cardiac safety remains the leading cause of drug development discontinuation. We developed a human cardiomyocyte-based model that has the potential to provide a predictive preclinical approach for simultaneously predicting drug-induced inotropic and

Externí odkaz: https://doaj.org/article/97038ffc628241a5a180e8e55611c140

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Low-energy cardioversion of ventricular tachycardia: When less is more

Autor: Francesco Moretti, Philippe Meyer, Haran Burri

Publikováno v: Indian Pacing and Electrophysiology Journal, Vol 17, Iss 2, Pp 44-47 (2017)
Indian Pacing and Electrophysiology Journal, Vol. 17, No 2 (2017) pp. 44-47
Indian Pacing and Electrophysiology Journal

Herein we report the case of a patient who was admitted in ventricular tachycardia after having received multiple ineffective (and sometimes pro-arrhythmic) high-energy internal shocks from his ICD and who was finally successfully treated by a comman

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ecddfa0f2491ed7d475c6cf865d367
https://doi.org/10.1016/j.ipej.2017.02.002

Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk

Autor: Phachareeya Ratchada, Paul Miller, William Nguyen, Andrea Ghetti, Nathalie Nguyen, Najah Abi-Gerges, Brynna Nguyenton, Guy Page

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 8 (2017)

Cardiac safety remains the leading cause of drug development discontinuation. We developed a human cardiomyocyte-based model that has the potential to provide a predictive preclinical approach for simultaneously predicting drug-induced inotropic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedd96f31bb71a957eae77f82ffb2bcc
http://europepmc.org/articles/PMC5742250