Zobrazeno 1 - 10
of 546
pro vyhledávání: '"prmt"'
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Histone methylation is an important type of histone modification that regulates gene expression in plants. In this study, we identified 14 arginine methylation-related genes (Protein Arginine Methyltransferase, MdPRMT) and 32 demethylation-related ge
Externí odkaz:
https://doaj.org/article/a4cb9fb5f19d451b9f7d9534fe02ade4
Publikováno v:
Waike lilun yu shijian, Vol 28, Iss 06, Pp 563-567 (2023)
Protein lysine methyltransferases (PKMT) catalyze methylation of lysine residues on histone tails and non-histone targets. These important post-translational modifications affect the structure and compactness of chromatin, which in turn affects gene
Externí odkaz:
https://doaj.org/article/bcefc1addb5e4568ba6143cdeb74925f
Autor:
Anna J Kordala, Jessica Stoodley, Nina Ahlskog, Muhammad Hanifi, Antonio Garcia Guerra, Amarjit Bhomra, Wooi Fang Lim, Lyndsay M Murray, Kevin Talbot, Suzan M Hammond, Matthew JA Wood, Carlo Rinaldi
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-16 (2023)
Abstract Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality. The advent of approved treatments for this devastating condition has significantly changed SMA patients' life expectancy and quality of life. Nevertheless, these a
Externí odkaz:
https://doaj.org/article/0a6be327d14849d1ae2a1fc49bf73886
Autor:
Linfeng Chen, Qiming Tang, Keying Zhang, Qianyang Huang, Yun Ding, Bo Jin, Szumam Liu, KuoYuan Hwa, C. James Chou, Yani Zhang, Sheeno Thyparambil, Weili Liao, Zhi Han, Richard Mortensen, James Schilling, Zhen Li, Robert Heaton, Lu Tian, Harvey J. Cohen, Karl G. Sylvester, Rebecca C. Arent, Xinyang Zhao, Doff B. McElhinney, Yumei Wu, Wenpei Bai, Xuefeng B. Ling
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Motivation Ovarian cancer (OC) is a highly lethal gynecological malignancy. Extensive research has shown that OC cells undergo significant metabolic alterations during tumorigenesis. In this study, we aim to leverage these metabolic changes
Externí odkaz:
https://doaj.org/article/6a07bee1d1604685ad0ecd1e90a88f63
Autor:
Yusuke Amano, Daisuke Matsubara, Atsushi Kihara, Taichiro Yoshimoto, Noriyoshi Fukushima, Hiroshi Nishino, Yoshiyuki Mori, Toshiro Niki
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionThe Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway protein e
Externí odkaz:
https://doaj.org/article/936860388cd4499888d34154fd362794
Autor:
Jujun Zhou, John R. Horton, Dan Yu, Ren Ren, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng
Publikováno v:
Epigenetics, Vol 17, Iss 9, Pp 970-981 (2022)
Epigenetically targeted therapeutic development, particularly for SAM-dependent methylations of DNA, mRNA and histones has been proceeding rapidly for cancer treatments over the past few years. However, this approach has barely begun to be exploited
Externí odkaz:
https://doaj.org/article/5a7bb73e66d04b97acf84d95ef8faf4c
Autor:
Claudia Dominici, Oscar D Villarreal, Junio Dort, Emilie Heckel, Yu Chang Wang, Ioannis Ragoussis, Jean-Sebastien Joyal, Nicolas Dumont, Stéphane Richard
Publikováno v:
eLife, Vol 12 (2023)
In skeletal muscle, muscle stem cells (MuSC) are the main cells responsible for regeneration upon injury. In diseased skeletal muscle, it would be therapeutically advantageous to replace defective MuSCs, or rejuvenate them with drugs to enhance their
Externí odkaz:
https://doaj.org/article/f457c027fbc9429c8371d06ee36f86bb
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionIntronic repeat expansions in the C9orf72 gene are the most frequent known single genetic causes of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These repeat expansions are believed to result in both loss-of-func
Externí odkaz:
https://doaj.org/article/923b09c8034a407e887177a22f52d0e7
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Recent studies highlighted the functional role of protein arginine methyltransferases (PRMTs) catalyzing the methylation of protein arginine in malignant progression of various tumors. Stratification the subtypes of hepatocellular carcino
Externí odkaz:
https://doaj.org/article/654065da5d944af5bdb5d2617020872d
Publikováno v:
Epigenetics, Vol 17, Iss 1, Pp 1-18 (2022)
Histone arginine methylation is a prevalent posttranslational modification (PTM) in eukaryotic cells and contributes to the histone codes for epigenetic regulation of gene transcription. In this study, we determined how local changes on adjacent resi
Externí odkaz:
https://doaj.org/article/d699dc005ded4b4988324f64f18e8826