MiR-128-1-5p inhibits cell proliferation and induces cell apoptosis via targeting PRKCQ in colorectal cancer

Autor: Qingan Jia, Xia Liao, Binghui Xu, Yufang Li, Lei Liang

Publikováno v: Cancer Biology & Therapy, Vol 24, Iss 1 (2023)

Previous studies have indicated that miR-128 was downregulated in a variety of cancers including colorectal cancer (CRC). However, the role and the underlying molecular mechanisms of miR-128 in CRC still remain largely unknown. The aim of this study

Externí odkaz: https://doaj.org/article/83e08c58308644928f73da4d3291cca2

The expression of microRNAs and exposure to environmental contaminants related to human health: a review

Autor: Francesca Di Serio, Carlo Giacomo Leo, Francesco Bagordo, Tiziana Grassi, Antonella De Donno, Saverio Sabina, Adele Idolo, Roberto Guarino, Alessandra Panico, Pierpaolo Mincarone, Maria Rosaria Tumolo

Publikováno v: International journal of environmental health research
(2020): 1–23. doi:10.1080/09603123.2020.1757043.
info:cnr-pdr/source/autori:Tumolo M.R., Panico A., De Donno A., Mincarone P., Leo C.G., Guarino R., Bagordo F., Serio F., Idolo A., Grassi T., Sabina S./titolo:The expression of microRNAs and exposure to environmental contaminants related to human health: a review./doi:10.1080%2F09603123.2020.1757043./rivista:International journal of environmental health research (Print)/anno:2020/pagina_da:1/pagina_a:23/intervallo_pagine:1–23/volume

Environmental contaminants exposure may lead to detrimental changes to the microRNAs (miRNAs) expression resulting in several health effects. miRNAs, small non-coding RNAs that regulate gene expression, have multiple transcript targets and thereby re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0173a25e7b4ea295ebd52293ca1b875d
https://doi.org/10.1080/09603123.2020.1757043

Cyclin D1 is a mediator of gastrointestinal stromal tumor KIT-independence

Autor: Meijun Zhu, Jonathan A. Fletcher, Haibo Qiu, Duolin Wu, Wen-Bin Ou, Grant Eilers, Weihao Zhuang, Nan Ni, Bin Li, Rui Zuo, George D. Demetri, Anastasios Kyriazoglou, Adrián Mariño-Enríquez

Publikováno v: Oncogene. 38:6615-6629

Oncogenic KIT or PDGFRA tyrosine kinase mutations are compelling therapeutic targets in most gastrointestinal stromal tumors (GISTs), and the KIT inhibitor, imatinib, is therefore standard of care for patients with metastatic GIST. However, some GIST

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d470f0d3b0b7306b5bb8811e94ac8f
https://doi.org/10.1038/s41388-019-0894-3

A 4 Gene-based Immune Signature Predicts Dedifferentiation and Immune Exhaustion in Thyroid Cancer

Autor: Yu-Long Wang, Cui-Wei Li, Tian Liao, Ben Ma, Qinghai Ji, Zhongwu Lu, Yu Wang, Xiao Shi, Wen-Jun Wei

Publikováno v: The Journal of clinical endocrinology and metabolism. 106(8)

Context The role of immune-related genes (IRGs) in thyroid cancer dedifferentiation and accompanying immune exhaustion remains largely unexplored. Objective To construct a significant IRG-based signature indicative of dedifferentiation and immune exh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cb0bc4c3bb013d8543d42301eb48f7
https://pubmed.ncbi.nlm.nih.gov/33656532

Protein kinase C theta (Prkcq) affects nerve degeneration and regeneration through the c-fos and c-jun pathways in injured rat sciatic nerves

Autor: Dengbing Yao, Nannan Gao, Min Cai, Huanhuan Zhang, Yi Wang, Yumei Feng, Xi Xu, Yuting Li

Publikováno v: Experimental Neurology. 346:113843

Background Previous finding using DNA microarray and bioinformatics analysis, we have reported some key factors which regulated gene expression and signaling pathways in injured sciatic nerve during Wallerian Degeneration (WD). This research is focus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368e49db033cc8d0902793701d99e591
https://doi.org/10.1016/j.expneurol.2021.113843