Zobrazeno 1 - 10
of 58
pro vyhledávání: '"prion-like spreading"'
Autor:
Sara Elfarrash, Nanna Møller Jensen, Nelson Ferreira, Cristine Betzer, Jervis Vermal Thevathasan, Robin Diekmann, Mohamed Adel, Nisreen Mansour Omar, Mohamed Z. Boraie, Sabry Gad, Jonas Ries, Deniz Kirik, Sadegh Nabavi, Poul Henning Jensen
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF injection at dentate gyrus (DG)
Externí odkaz:
https://doaj.org/article/10fb2dc993f841539e1e8dae921a245c
Autor:
Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Alpha-synuclein inclusions, the hallmarks of synucleinopathies, are suggested to spread along neuronal connections in a stereotypical pattern in the brains of patients. Ample evidence now supports that pathological forms of alpha-synuclein p
Externí odkaz:
https://doaj.org/article/392d3687fdd945a8b98109737c3aa20d
Autor:
Lien Veys, Jessie Van houcke, Jeroen Aerts, Sophie Van Pottelberge, Michel Mahieu, Audrey Coens, Ronald Melki, Dieder Moechars, Louis De Muynck, Lies De Groef
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2021)
Although very different in etiology and symptoms, numerous neurodegenerative diseases can be classified as proteinopathies. More so, evidence indicates that the key misfolded proteins at the basis of different neuropathies might share common mechanis
Externí odkaz:
https://doaj.org/article/bbe320cb208e42e49fedff55771c3610
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-related neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral scl
Externí odkaz:
https://doaj.org/article/1a1dcab971cc444794226da42e263381
Autor:
Inês C. Brás, Tiago F. Outeiro
Publikováno v:
Cells, Vol 10, Iss 2, p 375 (2021)
The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson’s disease (PD) pathogenesis. The stereotypical distribution and evolution of the pathology during disease is often at
Externí odkaz:
https://doaj.org/article/95a4dccd3e37416fa9d1509c99774b6a
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 1, Pp 31-39 (2014)
Caenorhabditis elegans has a number of distinct advantages that are useful for understanding the basis for cellular and organismal dysfunction underlying age-associated diseases of protein misfolding. Although protein aggregation, a key feature of hu
Externí odkaz:
https://doaj.org/article/1a54dfc36923448a8f29f68a00b571bf
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10093, p 10093 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Multiple system atrophy (MSA) is a rapidly progressive, fatal neurodegenerative disease of uncertain aetiology that belongs to the family of α-synucleinopathies. It clinically presents with parkinsonism, cerebellar, autonomic, and motor impairment i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c3d1f231ce846cfee495f72cf90727
https://www.mdpi.com/1422-0067/22/18/10093
https://www.mdpi.com/1422-0067/22/18/10093
Autor:
Michel Mahieu, Lies De Groef, Jessie Van Houcke, Sophie Van Pottelberge, Dieder Moechars, Jeroen Aerts, Lien Veys, Audrey Coens, Ronald Melki, Louis De Muynck
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 12 (2021)
Frontiers in Aging Neuroscience, 2021, 12, pp.614587. ⟨10.3389/fnagi.2020.614587⟩
Frontiers in Aging Neuroscience, Frontiers, 2021, 12, pp.614587. ⟨10.3389/fnagi.2020.614587⟩
Frontiers in Aging Neuroscience, Vol 12 (2021)
Frontiers in Aging Neuroscience, 2021, 12, pp.614587. ⟨10.3389/fnagi.2020.614587⟩
Frontiers in Aging Neuroscience, Frontiers, 2021, 12, pp.614587. ⟨10.3389/fnagi.2020.614587⟩
Although very different in etiology and symptoms, numerous neurodegenerative diseases can be classified as proteinopathies. More so, evidence indicates that the key misfolded proteins at the basis of different neuropathies might share common mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635cd3e6071dbceec1dda45168b930fa
https://pubmed.ncbi.nlm.nih.gov/33519421
https://pubmed.ncbi.nlm.nih.gov/33519421
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 12 (2020)
Frontiers in Aging Neuroscience, Vol 12 (2020)
Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf3f403019fcb7010b3c8cbd3379a8a
https://pubmed.ncbi.nlm.nih.gov/33132902
https://pubmed.ncbi.nlm.nih.gov/33132902