Zobrazeno 1 - 10
of 1 273
pro vyhledávání: '"primordial follicle"'
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 288, Iss , Pp 117302- (2024)
The ovarian reserve consists of a limited supply of primordial follicles (PFs), each containing an oocyte surrounded by a layer of granulosa cells (GCs). PFs are relatively quiescent and must remain viable for a long period, thereby making them susce
Externí odkaz:
https://doaj.org/article/1545ad1765ed4d6ba6df4d9ec5155764
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionThe mechanisms leading to ovarian primordial follicle depletion following gonadotoxic chemotherapy with cyclophosphamide and other cytotoxic drugs are currently understood through two main explanatory theories: apoptosis and over-activati
Externí odkaz:
https://doaj.org/article/fb1ec61ea138453f988d51abd7bfb6da
Autor:
Jacinta H. Martin, Ilana R. Bernstein, Jess M. Lyons, Ariel R. Brady, Nishani S. Mabotuwana, Simone J. Stanger, Camila Salum De Oliveira, Katerina B. Damyanova, Brett Nixon, Tessa Lord
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Oxygen availability can have profound effects on cell fate decisions and survival, in part by regulating expression of hypoxia-inducible factors (HIFs). In the ovary, HIF expression has been characterised in granulosa cells, however, any req
Externí odkaz:
https://doaj.org/article/5dda65dc8bf448c0add10432000f1a06
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background CircRNAs are a class of noncoding RNAs with tissue- and development-specific expression characteristics. In many mammals, primordial follicle development begins in the embryonic stage. However, the study of circRNAs in primordial
Externí odkaz:
https://doaj.org/article/0ef3d3a815134a1b94f32d60e5fd63f6
Autor:
Seyedeh Nasim Mirbahari, Christiani A. Amorim, Fatemeh Hassani, Mehdi Totonchi, Mahnaz Haddadi, Mojtaba Rezazadeh valojerdi, Azam Dalman
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Background The objective of this study was to induce the differentiation of human theca stem cells (hTSCs) into germ cell-like cells (hGCLCs) and assess their developmental progression following in vitro 3D culture with ovarian somatic cells
Externí odkaz:
https://doaj.org/article/d4c87ec628b844299b1636f8c833cd4f
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32802- (2024)
Background: The phosphoinositide 3-kinase/Akt/mammalian target of rapamycin complex 1 (PI3K/Akt/mTORC1) pathway plays a crucial role in the activation of primordial follicles. However, excessive activation and the loss of primordial follicles can lea
Externí odkaz:
https://doaj.org/article/9cb6e1903c1343508301076418003850
Publikováno v:
Bioengineering, Vol 11, Iss 7, p 734 (2024)
The only fertility preservation and subsequent restoration option for many patients facing gonadotoxic treatments is ovarian tissue cryopreservation and transplantation. While this process is successful for some, there is significant room for improve
Externí odkaz:
https://doaj.org/article/ac7ec983c58a41d887db54c8a90b64a9
Autor:
Li Liu, Biting Liu, Lian Wang, Caixia Li, Yang Zhou, Jihui Zhu, Jinye Ding, Shupeng Liu, Zhongping Cheng
Publikováno v:
Reproductive Biology and Endocrinology, Vol 21, Iss 1, Pp 1-7 (2023)
Abstract Efficient evaluation of the primordial follicle pool (PFP) of mammalian models is an essential subject in biomedical research relating to ovarian physiology and pathogenesis. Our recent study has identified a gene signature including Sohlh1,
Externí odkaz:
https://doaj.org/article/0fdb0af61b104d65ad59820a128a2846
Autor:
V. Praveen Chakravarthi, Iman Dilower, Subhra Ghosh, Shaon Borosha, Ryan Mohamadi, Vinesh Dahiya, Kevin Vo, Eun B. Lee, Anamika Ratri, Vishnu Kumar, Courtney A. Marsh, Patrick E. Fields, M. A. Karim Rumi
Publikováno v:
Cells, Vol 13, Iss 7, p 644 (2024)
Increased activation of ovarian primordial follicles in Erβ knockout (ErβKO) rats becomes evident as early as postnatal day 8.5. To identify the ERβ-regulated genes that may control ovarian primordial follicle activation, we analyzed the transcrip
Externí odkaz:
https://doaj.org/article/98170437141341f7a274ecb6285be4a1
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe number of primordial follicles (PFs) in mammals determines the ovarian reserve, and impairment of primordial follicle formation (PFF) will cause premature ovarian insufficiency (POI).MethodsBy analyzing public single-cell RNA sequenci
Externí odkaz:
https://doaj.org/article/7230b2eb96504e9f84e1469054897bb9