Zobrazeno 1 - 10
of 496
pro vyhledávání: '"primary hepatocyte"'
Autor:
Asako Murayama, Hitomi Igarashi, Norie Yamada, Hussein Hassan Aly, Masaaki Toyama, Masanori Isogawa, Tetsuro Shimakami, Takanobu Kato
Publikováno v:
mSphere, Vol 9, Iss 10 (2024)
ABSTRACT A cell culture system that allows the reproduction of the hepatitis B virus (HBV) life cycle is indispensable to exploring novel anti-HBV agents. To establish the screening system for anti-HBV agents, we exploited the high affinity and brigh
Externí odkaz:
https://doaj.org/article/4e51fd3150b94cc8b5c05cdcc7fc5ca9
Autor:
Jie Wei, Bo Zhang, Jing Tang, Junting Cao, Chenchen Du, Zhen Wang, Yunsheng Zhang, Ming Xie, Zhengkui Zhou, Shuisheng Hou
Publikováno v:
Poultry Science, Vol 103, Iss 4, Pp 103531- (2024)
ABSTRACT: Primary hepatocytes (PH) have been widely used in metabolic and disease-resistance mechanism research. However, hepatocyte isolation (HI) remains challenging in ducks. This study aimed to explore embryonic growth and the effect of embryonic
Externí odkaz:
https://doaj.org/article/1fbfcb819d244957b699a6871c2f66fd
Autor:
LU Yan, ZHOU Yabo, CHEN Jie
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 4, Pp 554-559 (2023)
Objective Construction of mouse liver senescence model induced rapidly in vitro by 3D organoid culture. Methods Mouse hepatocytes were collected by two-step perfusion method and cultured in 3D. Organoids were preliminarily identified by morphology, q
Externí odkaz:
https://doaj.org/article/a25ac52081074d10ba67d91f1da5cfe6
Three-Dimensional Hepatocyte Spheroids: Model for Assessing Chemotherapy in Hepatocellular Carcinoma
Autor:
Felix Royo, Clara Garcia-Vallicrosa, Maria Azparren-Angulo, Guillermo Bordanaba-Florit, Silvia Lopez-Sarrio, Juan Manuel Falcon-Perez
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1200 (2024)
Background: Three-dimensional cellular models provide a more comprehensive representation of in vivo cell properties, encompassing physiological characteristics and drug susceptibility. Methods: Primary hepatocytes were seeded in ultra-low attachment
Externí odkaz:
https://doaj.org/article/1ec0de80f3f7465abc25c9e62a5810d0
Autor:
Guang-Peng Zhou, Shi-Peng Li, Yi-Zhou Jiang, Jie Sun, Yu-Le Tan, Zhi-Gui Zeng, Lin Wei, Wei Qu, Li-Ying Sun, Zhi-Jun Zhu
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Explanted livers from patients with inherited metabolic liver diseases possess the potential to be a cell source of good-quality hepatocytes for hepatocyte transplantation (HT). This study evaluated the therapeutic effects of domi
Externí odkaz:
https://doaj.org/article/4c5a378bd865462cb316c5ecc2458d3d
Autor:
Yoko Sakai, Masanari Matsumura, Hideki Yamada, Atsushi Doi, Isao Saito, Takahiro Iwao, Tamihide Matsunaga
Publikováno v:
Applied Sciences, Vol 13, Iss 18, p 10510 (2023)
There is an increasing need to develop alternatives to animal modeling and testing for pre-clinical studies as researchers face major challenges, such as the study of dynamic systems in laboratory settings. Microphysiological system (MPS) technology
Externí odkaz:
https://doaj.org/article/fcdd1806848f43bcb45bc99bca525fdf
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Takayuki Murata, Satoko Iwahori, Yusuke Okuno, Hironori Nishitsuji, Yusuke Yanagi, Koichi Watashi, Takaji Wakita, Hiroshi Kimura, Kunitada Shimotohno
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2265 (2023)
N6-methyladenosine (m6A) is a post-transcriptional modification of RNA involved in transcript transport, degradation, translation, and splicing. We found that HBV RNA is modified by m6A predominantly in the coding region of HBx. The mutagenesis of me
Externí odkaz:
https://doaj.org/article/d95be18c87434a6a8634124f31893640