Zobrazeno 1 - 10
of 369
pro vyhledávání: '"primary glioblastoma"'
Publikováno v:
Türk Patoloji Dergisi, Vol 38, Iss 2, Pp 090-098 (2022)
Objective: Diffuse gliomas, the most common primary malignant brain tumors, have been classified by the World Health Organization as class II-IV gliomas. After 2016, two mutations in the promoter region of the telomerase reverse transcriptase (TERT)
Externí odkaz:
https://doaj.org/article/6cd509014f2245ca84a0796015c82748
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundAlthough isocitrate dehydrogenase (IDH) mutation serves as a prognostic signature for routine clinical management of glioma, nearly 90% of glioblastomas (GBM) patients have a wild-type IDH genotype (IDHWT) and lack reliable signatures to id
Externí odkaz:
https://doaj.org/article/b6666ddfdc914da7a234710f4f82531f
Autor:
M. V. Matsko, S. S. Sklyar, A. Yu. Ulitin, D. E. Matsko, E. N. Imyanitov, A. G. Ievleva, V. I. Ni, N. M. Volkov, A. A. Zrelov, A. O. Baksheeva, D. V. Galkina
Publikováno v:
Сибирский онкологический журнал, Vol 20, Iss 3, Pp 5-17 (2021)
Background. Over the past 10–15 years, there has been a clearer understanding of the processes occurring in cells of the primary glioblastoma. However, the change in MGMT gene expression and its role after disease relapse remain understudied. Purpo
Externí odkaz:
https://doaj.org/article/2ffd88be1f934763882aaab2a04c4719
Autor:
Chao Gan, Daniela Pierscianek, Nicolai El Hindy, Yahya Ahmadipour, Kathy Keyvani, Ulrich Sure, Yuan Zhu
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background ALDH1A3 is a cancer stem cell marker in neoplasms including glioblastoma (GBM). However, the comprehensive role of ALDH1A3 in GBM remains unclear. This study attempted to investigate the expression of ALDH1A3 in human GBM tissues
Externí odkaz:
https://doaj.org/article/49d758faebab41a1a55a2e5a6a18ab20
Publikováno v:
Journal of Integrative Neuroscience, Vol 21, Iss 3, p 86 (2022)
Background: Some evidence about the role of the androgen receptor (AR) in pathogenesis of glioblastoma have been reported, but no study has focused on measuring the activity of the AR in GB. Therefore, the aim of this work is to study the role of AR
Externí odkaz:
https://doaj.org/article/b25e90e4cba44b92ac2db9da1163787d
Autor:
Omer Gokay Argadal, Melis Mutlu, Secil Ak Aksoy, Hasan Kocaeli, Berrin Tunca, Muhammet Nafi Civan, Unal Egeli, Gulsah Cecener, Ahmet Bekar, Mevlut Ozgur Taskapilioglu, Cagla Tekin, Gulcin Tezcan, Sahsine Tolunay
Publikováno v:
Biomolecules & Biomedicine, Vol 20, Iss 1 (2020)
Primary glioblastoma (GB) is the most aggressive type of brain tumors. While mutations in isocitrate dehydrogenase (IDH) genes are frequent in secondary GBs and correlate with a better prognosis, most primary GBs are IDH wild-type. Recent studies hav
Externí odkaz:
https://doaj.org/article/c58fd194674d45f3a11d086ac335a20d
Publikováno v:
Glioma, Vol 1, Iss 2, Pp 59-65 (2018)
Background: Delta-like ligand 4 (DLL4) is a key Notch ligand implicated in tumor angiogenesis. However, previous studies have shown that the DLL4-Notch signaling inhibits tumor angiogenesis but promotes tumor progression in primary glioblastoma. The
Externí odkaz:
https://doaj.org/article/88687a7bf0bb421095ca97c90e462093
Publikováno v:
Cellular Physiology and Biochemistry, Vol 44, Iss 4, Pp 1591-1605 (2017)
Background/Aims: Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug is used to treat epileptic seizure of glioblastoma patients. Besides its antiepileptic activity, VPA has been attributed further functions that improve the clinical out
Externí odkaz:
https://doaj.org/article/a772ec87b2ad479390b20678b4a98260
Autor:
Haorun Wang, Shenjie Li, Ligang Chen, Jian-Mei Wang, Xing-Zhao Luan, Haiping He, Jie Zhou, Wei Xiang
Publikováno v:
World Journal of Clinical Cases
BACKGROUND Glioblastoma has a high degree of malignancy and poor prognosis. It is common to have in situ recurrence and intracranial metastasis, while extracranial metastasis is rare, and extracranial multiorgan metastasis is extremely rare. We repor
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