Zobrazeno 1 - 10
of 552
pro vyhledávání: '"presynaptic active zone"'
Publikováno v:
Neural Development, Vol 15, Iss 1, Pp 1-17 (2020)
Abstract Synapses are the sites of neuron-to-neuron communication and form the basis of the neural circuits that underlie all animal cognition and behavior. Chemical synapses are specialized asymmetric junctions between a presynaptic neuron and a pos
Externí odkaz:
https://doaj.org/article/04d17da26a5544e7aa9bd17d6952b680
Publikováno v:
Frontiers in Neuroanatomy, Vol 16 (2022)
Upon the arrival of action potentials at nerve terminals, neurotransmitters are released from synaptic vesicles (SVs) by exocytosis. CaV2.1, 2.2, and 2.3 are the major subunits of the voltage-gated calcium channel (VGCC) responsible for increasing in
Externí odkaz:
https://doaj.org/article/65ed7e758c5a4ceaa43a44da2fda089d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Brain’s functions, such as memory and learning, rely on synapses that are highly specialized cellular junctions connecting neurons. Functional synapses orchestrate the assembly of ion channels, receptors, enzymes, and scaffold proteins in both pre-
Externí odkaz:
https://doaj.org/article/627860cdfcc745e8bfcfbe0b6e8f4d3e
Autor:
Mingfu Liang, Gaowei Jin, Xingqiao Xie, Wenchao Zhang, Kaiyue Li, Fengfeng Niu, Cong Yu, Zhiyi Wei
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108901- (2021)
Summary: Synaptic scaffold proteins (e.g., liprin-α, ELKS, RIM, and RIM-BP) orchestrate ion channels, receptors, and enzymes at presynaptic terminals to form active zones for neurotransmitter release. The underlying mechanism of the active zone asse
Externí odkaz:
https://doaj.org/article/16f21cca12224e27a2fdf903a3c491be
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Autor:
Sumiko Mochida, Yamato Hida, Shota Tanifuji, Akari Hagiwara, Shun Hamada, Manabu Abe, Huan Ma, Misato Yasumura, Isao Kitajima, Kenji Sakimura, Toshihisa Ohtsuka
Publikováno v:
Cell Reports, Vol 16, Iss 11, Pp 2901-2913 (2016)
Short-term synaptic depression (STD) is a common form of activity-dependent plasticity observed widely in the nervous system. Few molecular pathways that control STD have been described, but the active zone (AZ) release apparatus provides a possible
Externí odkaz:
https://doaj.org/article/f666f1de962349539dbcc7ad73ff9e31
Autor:
Jens Weingarten, Melanie Laßek, Benjamin F. Mueller, Marion Rohmer, Dominic Baeumlisberger, Benedikt Beckert, Jens Ade, Patricia Gogesch, Amparo Acker-Palmer, Michael Karas, Walter Volknandt
Publikováno v:
Proteomes, Vol 3, Iss 2, Pp 74-88 (2015)
Neurotransmitter release as well as structural and functional dynamics at the presynaptic active zone (PAZ) comprising synaptic vesicles attached to the presynaptic plasma membrane are mediated and controlled by its proteinaceous components. Here we
Externí odkaz:
https://doaj.org/article/b8d1293d2bdc4cdf8fbe0dc83f95f3e0
Autor:
Peter Koppensteiner, Theocharis Alvanos, Carolin Wichmann, Anika Hintze, Tobias Moser, Tanvi Butola, David Kleindienst, Ryuichi Shigemoto
Publikováno v:
The Journal of Neuroscience. 41:7742-7767
Rab-interacting molecule (RIM)-binding protein 2 (BP2) is a multidomain protein of the presynaptic active zone (AZ). By binding to RIM, bassoon (Bsn), and voltage-gated Ca2+ channels (CaV), it is considered to be a central organizer of the topography
Publikováno v:
Proteomes, Vol 2, Iss 2, Pp 243-257 (2014)
The proteome of the presynaptic active zone controls neurotransmitter release and the short- and long-term structural and functional dynamics of the nerve terminal. The proteinaceous inventory of the presynaptic active zone has recently been reported
Externí odkaz:
https://doaj.org/article/ae06447567c24c70bc4dd93bda1fbf81
Publikováno v:
J Neurosci
Presynaptic active zone proteins couple calcium influx with synaptic vesicle exocytosis. However, the control of presynaptic calcium channel clustering by active zone proteins is not completely understood. In aC. elegansforward genetic screen, we fin