Zobrazeno 1 - 10
of 3 388
pro vyhledávání: '"preclinical research"'
Publikováno v:
Addiction. Jun2022, Vol. 117 Issue 6, p1820-1822. 3p.
Publikováno v:
ESC Heart Failure, Vol 11, Iss 3, Pp 1283-1289 (2024)
Abstract Heart failure is a devastating syndrome affecting an increasingly high number of patients worldwide. Its aetiology and pathogenesis are complex with the involvement of factors ranging from the genetic material through valvular dysfunctions t
Externí odkaz:
https://doaj.org/article/e0af5814423a4274a366a42adfd40ecb
Autor:
Julia E. Altman, Amy L. Olex, Emily K. Zboril, Carson J. Walker, David C. Boyd, Rachel K. Myrick, Nicole S. Hairr, Jennifer E. Koblinski, Madhavi Puchalapalli, Bin Hu, Mikhail G. Dozmorov, X. Steven Chen, Yunshun Chen, Charles M. Perou, Brian D. Lehmann, Jane E. Visvader, J. Chuck Harrell
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 10, Pp n/a-n/a (2024)
Abstract Background Breast cancer's complex transcriptional landscape requires an improved understanding of cellular diversity to identify effective treatments. The study of genetic variations among breast cancer subtypes at single‐cell resolution
Externí odkaz:
https://doaj.org/article/d0c391dda0a74b8395d749dfd6add293
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Silent information regulator 1 (SIRT1) is a NAD+-dependent class III deacetylase that plays important roles in the pathogenesis of numerous diseases, positioning it as a prime candidate for therapeutic intervention. Among its modulators, SRT
Externí odkaz:
https://doaj.org/article/fbe62b859aaa4faa9a9137cf127c20cc
Autor:
Pádraig Carroll, Éimear Smith, Adrian Dervan, Ciarán McCarthy, Ian Woods, Cliff Beirne, Geoff Harte, Dónal O'Flynn, John Quinlan, Fergal J. O'Brien, Michelle Flood, Frank Moriarty
Publikováno v:
Health Expectations, Vol 27, Iss 4, Pp n/a-n/a (2024)
Abstract Introduction There is currently limited guidance for researchers on Patient and Public Involvement (PPI) for preclinical spinal cord research, leading to uncertainty about design and implementation. This study aimed to develop evidence‐inf
Externí odkaz:
https://doaj.org/article/4a7cae8c9b0b412d912186a9481fda32
Autor:
Mathias Tesson, Jennifer P. Morton
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/ecacb9b1cfeb43a58029acee1d9bf7c3
Autor:
Hanwei Yue, Lin Bai
Publikováno v:
Animal Models and Experimental Medicine, Vol 7, Iss 1, Pp 3-11 (2024)
Abstract In recent years, humanized immune system (HIS) mice have been gradually used as models for preclinical research in pharmacotherapies and cell therapies with major breakthroughs in tumor and other fields, better mimicking the human immune sys
Externí odkaz:
https://doaj.org/article/10057c4c05974220b25d87db6ac0b08c
Autor:
Manoj M. Lalu, Dawn Richards, Madison Foster, Brittany French, Angela M. Crawley, Kirsten M. Fiest, Kathryn Hendrick, Kimberly F. Macala, Asher A. Mendelson, Pat Messner, Stuart G. Nicholls, Justin Presseau, Cheryle A. Séguin, Patrick Sullivan, Bernard Thébaud, Dean A. Fergusson
Publikováno v:
Research Involvement and Engagement, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background Patient engagement in research is the meaningful and collaborative interaction between patients and researchers throughout the research process. Patient engagement can help to ensure patient-oriented values and perspectives are in
Externí odkaz:
https://doaj.org/article/d1346b77fe94404e9245270fe80b7977
Autor:
Alexandra Bannach-Brown, Torsten Rackoll, Nurcennet Kaynak, Natascha Drude, René Aquarius, Sofija Vojvodić, Mariana Abreu, Julia M. L. Menon, Kimberley E. Wever
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Systematic reviews are an essential tool in identifying knowledge gaps and synthesizing evidence from in vivo animal research to improve human health. The review process follows an explicit and systematic methodology to minimize bias, but is
Externí odkaz:
https://doaj.org/article/f3a29a5051a84b2b924dbd2ba561f5f6
Autor:
Thomas Hartung
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Animals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal mod
Externí odkaz:
https://doaj.org/article/d6c68c28933a414db9c90ffa3f8e778d