Zobrazeno 1 - 10
of 73
pro vyhledávání: '"precision-cut intestinal slices"'
Autor:
Carin Biel, Anniek Kastermans, Janneke Heidema, Martin Pehrsson, Charlotte Henstra, Joachim Mortensen, Klaas Nico Faber, Peter Olinga
Publikováno v:
Cells, Vol 13, Iss 13, p 1084 (2024)
In Crohn’s Disease (CD), intestinal fibrosis is a prevalent yet unresolved complication arising from chronic and transmural inflammation. The histological assessment of CD intestines shows changes in tissue morphology in all the layers, including t
Externí odkaz:
https://doaj.org/article/47dd384992ff487e93c3b4e213ddb9fe
Akademický článek
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Autor:
Ondrej Martinec, Carin Biel, Inge A. M. de Graaf, Martin Huliciak, Koert P. de Jong, Frantisek Staud, Filip Cecka, Peter Olinga, Ivan Vokral, Lukas Cerveny
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug–drug interactions. Drug-mediated induction of intestinal ABCB1 is a clinically relevant phenomenon assoc
Externí odkaz:
https://doaj.org/article/4656e5a7685c434c9074223607aaa1a1
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 242 (2022)
The inhibition of P-glycoprotein (ABCB1) could lead to increased drug plasma concentrations and hence increase drug toxicity. The evaluation of a drug’s ability to inhibit ABCB1 is complicated by the presence of several transport-competent sites wi
Externí odkaz:
https://doaj.org/article/a7d669cc018f407d8db99b38117ab3e2
Autor:
Lisa Hung, Alper Celik, Xiaojun Yin, Kai Yu, Alireza Berenjy, Akash Kothari, Helena Obernolte, Julia E. M. Upton, Katrine Lindholm Bøgh, Gino R. Somers, Iram Siddiqui, Martin Grealish, Fayez A. Quereshy, Katherina Sewald, Priscilla P. L. Chiu, Thomas Eiwegger
Publikováno v:
Hung, L, Celik, A, Yin, X, Yu, K, Berenjy, A, Kothari, A, Obernolte, H, Upton, J E M, Lindholm Bøgh, K, Somers, G R, Siddiqui, I, Grealish, M, Quereshy, F A, Sewald, K, Chiu, P P L & Eiwegger, T 2023, ' Precision cut intestinal slices, a novel model of acute food allergic reactions ', Allergy, vol. 78, no. 2, pp. 500-511 . https://doi.org/10.1111/all.15579
Background: Food allergy affects up to 8% of the pediatric population. Despite ongoing efforts, treatment options remain limited. Novel models of food allergy are needed to study response patterns downstream of IgE-crosslinking and evaluate drugs mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f039022cf3c19f43574387d5f4d34871
https://pubmed.ncbi.nlm.nih.gov/36377289
https://pubmed.ncbi.nlm.nih.gov/36377289
Akademický článek
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Publikováno v:
Frontiers in Pharmacology. 12
P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug–drug interactions. Drug-mediated induction of intestinal ABCB1 is a clinically relevant phenomenon assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::e535b7786f131a4669d7898200e83c14
https://hdl.handle.net/11370/aa20d324-9112-4cd8-bd88-ab362d1709c5
https://hdl.handle.net/11370/aa20d324-9112-4cd8-bd88-ab362d1709c5
Autor:
Martinec, Ondrej, Biel, Carin, de Graaf, Inge A.M., Huliciak, Martin, de Jong, Koert P., Staud, Frantisek, Cecka, Filip, Olinga, Peter, Vokral, Ivan, Cerveny, Lukas
Publikováno v:
Frontiers in Pharmacology, 12:684156. Frontiers Media SA
P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug–drug interactions. Drug-mediated induction of intestinal ABCB1 is a clinically relevant phenomenon assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::7c0f66e750698a89200b089333816703
https://research.rug.nl/en/publications/aa20d324-9112-4cd8-bd88-ab362d1709c5
https://research.rug.nl/en/publications/aa20d324-9112-4cd8-bd88-ab362d1709c5
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Bao Tung Pham, Dorenda Oosterhuis, Peter Olinga, S. Suriguga, Raditya Iswandana, Henricus A. M. Mutsaers, Louise A van Wijk, Yvette J. M. Jansen, Theerut Luangmonkong
Publikováno v:
Inflammatory Bowel Diseases, 26(5), 678-686. LIPPINCOTT WILLIAMS & WILKINS
Iswandana, R, Pham, B T, Suriguga, S, Luangmonkong, T, van Wijk, L A, Jansen, Y J M, Oosterhuis, D, Maria Mutsaers, H A & Olinga, P 2020, ' Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs ', Inflammatory Bowel Diseases, vol. 26, no. 5, pp. 678-686 . https://doi.org/10.1093/ibd/izz329
Inflammatory Bowel Diseases
Iswandana, R, Pham, B T, Suriguga, S, Luangmonkong, T, van Wijk, L A, Jansen, Y J M, Oosterhuis, D, Maria Mutsaers, H A & Olinga, P 2020, ' Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs ', Inflammatory Bowel Diseases, vol. 26, no. 5, pp. 678-686 . https://doi.org/10.1093/ibd/izz329
Inflammatory Bowel Diseases
Background Intestinal fibrosis is a hallmark of Crohn’s disease. Here, we investigated the impact of several putative antifibrotic compounds on the expression of fibrosis markers using murine precision-cut intestinal slices. Methods Murine precisio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f07eb3c31b014f633eab024331fa8a
https://research.rug.nl/en/publications/f096b1a0-e9f4-47cd-b1c2-69313179b8e0
https://research.rug.nl/en/publications/f096b1a0-e9f4-47cd-b1c2-69313179b8e0