Zobrazeno 1 - 10
of 158
pro vyhledávání: '"precipitation inhibitor"'
Autor:
Jin Woo Park, Sa-Won Lee, Jun Hak Lee, Jun-Pil Jee, Han-Joo Maeng, Dong-Jin Jang, Kwan Hyung Cho
Publikováno v:
Molecules, Vol 29, Iss 22, p 5267 (2024)
This study aimed to develop a supersaturated liquid formulation (SSLF) to enhance the solubility and dissolution of pazopanib hydrochloride (PZH). SSLFs were prepared by a simple stirring method in a heated silicon oil bath (70 °C). PZH showed highl
Externí odkaz:
https://doaj.org/article/5fce0cb8c0074356a2452f0da895fa69
Publikováno v:
Carbohydrate Polymer Technologies and Applications, Vol 6, Iss , Pp 100389- (2023)
Weak base drugs tend to precipitate in the intestine, leading to a decrease in their bioavailability. Precipitation initiates with supersaturation due to a pH shift from the stomach to the small intestine. Using natural polymers as precipitation inhi
Externí odkaz:
https://doaj.org/article/5b3dff429f1944aebe7efadea7e693dc
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 8, Iss 1, Pp 1-20 (2022)
Abstract Background Pemigatinib is a small molecule tyrosine kinase inhibitor of fibroblast growth factor receptor inhibitors. The oral bioavailability of Pemigatinib is constricted due to its limited solubility at physiological pH. It is essential t
Externí odkaz:
https://doaj.org/article/094253457ce34e0b8d4e95ffc49effd7
Akademický článek
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Akademický článek
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Autor:
Yanxiong Gan, Yaxin Xu, Xue Zhang, Huiling Hu, Wenke Xiao, Zheng Yu, Tao Sun, Jinming Zhang, Chuanbiao Wen, Shichao Zheng
Publikováno v:
Molecules, Vol 28, Iss 19, p 6962 (2023)
As a subclass of the biopharmaceutical classification system (BCS) class II, basic drugs (BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in the gastrointestinal tract, leading to less qualified in vitro–in vivo correl
Externí odkaz:
https://doaj.org/article/2657ff59ed5b4dfbb9d8bfc702eea029
Akademický článek
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Autor:
Afnan Bany Odeh, Boushra El-Sayed, Matthias Manne Knopp, Thomas Rades, Lasse Ingerslev Blaabjerg
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1601 (2023)
Supersaturating drug delivery systems such as solid dispersions of a drug in a polymer are frequently used in pharmaceutical development to enable oral delivery of poorly soluble drugs. In this study, the influence of the concentration and molecular
Externí odkaz:
https://doaj.org/article/9f0b44c3424a47c4bb04908702ac93e4
Autor:
Kanghee Jo, Hyeongmin Kim, Prakash Khadka, Taejun Jang, Soo Jin Kim, Seong-Ha Hwang, Jaehwi Lee
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 15, Iss 3, Pp 336-346 (2020)
The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus (HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a super
Externí odkaz:
https://doaj.org/article/f94730f62d3a458a91da1d0851f47531
Autor:
Qiaoli Wu, Disang Feng, Zhengwei Huang, Minglong Chen, Dan Yang, Xin Pan, Chao Lu, Guilan Quan, Chuanbin Wu
Publikováno v:
Drug Delivery, Vol 27, Iss 1, Pp 1292-1300 (2020)
Mesoporous silica with uniform 2-D hexagonal pores has been newly employed as facile reservoir to impove the dissolution rate of water insoluble drugs. However, rapid drug release from mesoporous silica is usually accompanied by the generation of sup
Externí odkaz:
https://doaj.org/article/1b9177275de8443983bc7ba394186105