Zobrazeno 1 - 10
of 110
pro vyhledávání: '"pre-formed fibrils"'
Publikováno v:
Brain Research Bulletin, Vol 215, Iss , Pp 111024- (2024)
Parkinson's disease is a complex neurodegenerative disease characterized by progressive movement impairments. Predominant symptoms encompass resting tremor, bradykinesia, limb rigidity, and postural instability. In addition, it also includes a series
Externí odkaz:
https://doaj.org/article/f1943c43df5a4e968cd4bdf0daf16b91
Autor:
Dennison Trinh, Ahmad R. Israwi, Harsimar Brar, Jose E.A. Villafuerte, Ruella Laylo, Humaiyra Patel, Sabika Jafri, Lina Al Halabi, Shaumia Sinnathurai, Kiran Reehal, Alyssa Shi, Vayisnavei Gnanamanogaran, Natalie Garabedian, Ivy Pham, Drake Thrasher, Philippe P. Monnier, Laura A. Volpicelli-Daley, Joanne E. Nash
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106287- (2023)
In Parkinson's disease (PD), post-mortem studies in affected brain regions have demonstrated a decline in mitochondrial number and function. This combined with many studies in cell and animal models suggest that mitochondrial dysfunction is central t
Externí odkaz:
https://doaj.org/article/abdde603660f4750b3c1c40031749d55
Autor:
Maja L. Hansen, Malene Ambjørn, Mikkel N. Harndahl, Tau Benned-Jensen, Karina Fog, Kaare Bjerregaard-Andersen, Florence Sotty
Publikováno v:
Cells, Vol 13, Iss 3, p 253 (2024)
Protein aggregation is a predominant feature of many neurodegenerative diseases, including synucleinopathies, which are characterized by cellular inclusions containing α-Synuclein (αSyn) phosphorylated at serine 129 (pSer129). In the present study,
Externí odkaz:
https://doaj.org/article/1f73d3d8dfcd4f2d93d98d8e2b676757
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract Genetic and neuropathological evidence strongly implicates aberrant forms of α-synuclein in neurodegeneration. Antibodies specific for α-synuclein phosphorylated at serine 129 (pS129) are selective for the pathological protein aggregates t
Externí odkaz:
https://doaj.org/article/32492b2590f04bc79c6937d8dab78d2f
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2089 (2023)
In Parkinson’s disease (PD), gut inflammation is hypothesised to contribute to α-synuclein aggregation, but gastrointestinal α-synuclein expression is poorly characterised. Cationic arginine-rich peptides (CARPs) are an emerging therapeutic optio
Externí odkaz:
https://doaj.org/article/f1167c12c26642c089715e0db44a2a72
Autor:
Kristian Leite, Pretty Garg, F. Paul Spitzner, Sofia Guerin Darvas, Mathias Bähr, Viola Priesemann, Sebastian Kügler
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
α-synuclein (α-Syn) is intimately linked to synucleinopathies like Parkinson’s disease and dementia with Lewy bodies. However, the pathophysiological mechanisms that are triggered by this protein are still largely enigmatic. α-Syn overabundance
Externí odkaz:
https://doaj.org/article/24dc0e7485754e85828935a5cb57124f
Autor:
Elisabeth Dinter, Theodora Saridaki, Leonie Diederichs, Heinz Reichmann, Björn H. Falkenburger
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-11 (2020)
Abstract Parkinson’s disease (PD) is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity, and when these symptoms respond to dopaminergic medications. Yet in the last years there was a greater recognition of additional aspects
Externí odkaz:
https://doaj.org/article/344ea47ebac047bf8cda54261c922b4b
Autor:
Éva M. Szegő, Fabian Boß, Daniel Komnig, Charlott Gärtner, Lennart Höfs, Hamed Shaykhalishahi, Michael M. Wördehoff, Theodora Saridaki, Jörg B. Schulz, Wolfgang Hoyer, Björn H. Falkenburger
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Reducing α-synuclein pathology constitutes a plausible strategy against Parkinson’s disease. As we recently demonstrated, the β-wrapin protein AS69 binds an N-terminal region in monomeric α-synuclein, interferes with fibril nucleation, and reduc
Externí odkaz:
https://doaj.org/article/4afc3502a31946d28cb7ee107aa29503
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.