Zobrazeno 1 - 10
of 5 936
pro vyhledávání: '"pre‐clinical"'
Autor:
Grazia Canciello, Stefano Tozza, Gaetano Todde, Maria Nolano, Felice Borrelli, Giovanni Palumbo, Raffaella Lombardi, Emanuele Cassano, Wanda Acampa, Giovanni Esposito, Fiore Manganelli, Maria Angela Losi
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Background Hereditary transthyretin (ATTRv) amyloidosis is rare, autosomal dominant disease with a fatal outcome if left untreated. Early stages detection is crucial for intervention. We aimed identifying early indexes of cardiac involvement
Externí odkaz:
https://doaj.org/article/e0f914ae77504a098b92706b57c4566b
Autor:
Prasannakumar Palaniappan, Yana Knudsen, Sebastian Meyer, Chiara Gianoli, Katrin Schnürle, Matthias Würl, Jonathan Bortfeldt, Katia Parodi, Marco Riboldi
Publikováno v:
Zeitschrift für Medizinische Physik, Vol 34, Iss 4, Pp 521-532 (2024)
We present a multi-stage and multi-resolution deformable image registration framework for image-guidance at a small animal proton irradiation platform. The framework is based on list-mode proton radiographies acquired at different angles, which are u
Externí odkaz:
https://doaj.org/article/4a12881b28f6412dae3ea26836240d38
Autor:
Shahryar Rajai Firouzabadi, Ida Mohammadi, Kiana Ghafourian, Seyed Ali Mofidi, Shahrzad Rajaei Firouzabadi, Seyed Mahmoud Hashemi, Fahimeh Ramezani Tehrani, Kyana Jafarabady
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-22 (2024)
Abstract Background Primary ovarian insufficiency (POI) manifests with hormonal imbalances, menstrual irregularities, follicle loss, and infertility. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are emerging as a promising treatment
Externí odkaz:
https://doaj.org/article/1f2668a5b4b14480be38f47f5c9e2c52
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background The objective of the present study was to evaluate the effect of 3D printed teeth and virtual simulation system on the pre-clinical access cavity preparation training of senior dental undergraduates. Methods The 3D printed teeth w
Externí odkaz:
https://doaj.org/article/39d8349e2845400089c82d3dcdb6b1d9
Autor:
Afraa Mohammad, Anna Yurina, Tatiana Simonyan, Daniil Chistyakov, Rand Salman, Ksenia Zornikova, Elizaveta Minina, Apollinariya Bogolyubova
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundModular (universal) CAR T-platforms were developed to combat the limitations of traditional CAR-T therapy, allowing for multiple targeting of tumor-associated antigens and the ability to control CAR-T cell activity. The modular CAR-T platfo
Externí odkaz:
https://doaj.org/article/251b93d4cc564e9a8c705caea4bb5266
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Most investigations on the immune cell-activating potency of IgA used purified total IgA and/or specific isolated cell populations. As IgA2 has been reported to be more pro-inflammatory than IgA1, we aimed to employ a fast and convenient whole blood-
Externí odkaz:
https://doaj.org/article/ea7ecab5b77041fcbb8b26abd052cc22
Autor:
Jatinder Saini, Danielle P. Johnson Erickson, François Vander Stappen, Matt Ruth, Sunan Cui, Vanessa Gorman, Séverine Rossomme, Ning Cao, Eric C. Ford, Juergen Meyer, Charles Bloch, Tony Wong, Clemens Grassberger, Ramesh Rengan, Jing Zeng, Marco Schwarz
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThis manuscript describes modifications to a pencil beam scanning (PBS) proton gantry that enables ultra-high dose rates (UHDR) irradiation, including treatment planning and validation.MethodsBeamline modifications consisted of opening the
Externí odkaz:
https://doaj.org/article/a7b70fc01fc8469ab7c24cb831c62aca
Publikováno v:
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 60, Iss 1, Pp 1-4 (2024)
Abstract Researchers are constantly trying to develop therapeutic targets in neurodegenerative disorders like Alzheimer's dementia and Parkinson's disease. Despite enormous endeavors, there are several unmet needs. Several contradictory pathophysiolo
Externí odkaz:
https://doaj.org/article/942fc229d45447899d6d7945b3890464
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background The tumor microenvironment is profoundly heterogeneous particularly when comparing sites of metastases. Establishing the extent of this heterogeneity may provide guidance on how best to design lipid-based drug delivery systems to
Externí odkaz:
https://doaj.org/article/9192e449a6724fde9d21e119bf73a0bd