Zobrazeno 1 - 10
of 3 510
pro vyhledávání: '"pparα"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Liver cancer is the fourth leading cause of cancer-related deaths with a steadily increasing rate worldwide, as a well-known hallmark of liver cancer, metabolic alterations are related to liposomal changes, a common characteristic of primary
Externí odkaz:
https://doaj.org/article/305955e8eb414e9aae8aae5468883d8d
Autor:
Huangfan Xie, Guangya Li, Yunxi Fu, Nan Jiang, Simeng Yi, Xi Kong, Jihang Shi, Shigang Yin, Jianhua Peng, Yong Jiang, Shichun Lu, Hongkui Deng, Bingqing Xie
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Primary human hepatocytes (PHHs) are highly valuable for drug-metabolism evaluation, liver disease modeling and hepatocyte transplantation. However, their availability is significantly restricted due to limited donor sources, alon
Externí odkaz:
https://doaj.org/article/96fcbdc0735b4138afb414fad8ac0c42
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Liver cancer is the 4th most lethal form of cancer with a poor prognosis for patients worldwide. Dysregulation of lipid metabolism is related to FA oxidation alternation which can be modified by peroxisome proliferator-activated receptor-α
Externí odkaz:
https://doaj.org/article/94415d9074e844958880920d74593f69
Autor:
Shicheng Fan, Yue Gao, Pengfei Zhao, Guomin Xie, Yanying Zhou, Xiao Yang, Xuan Li, Shuaishuai Zhang, Frank J. Gonzalez, Aijuan Qu, Min Huang, Huichang Bi
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2992-3008 (2024)
Fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, is widely prescribed for hyperlipidemia management. Recent studies also showed that it has therapeutic potential in various liver diseases. However, its effects on hepatom
Externí odkaz:
https://doaj.org/article/ffaca6e6008341c9ac5e6816bba27d5b
Autor:
Linjie Pan, Zhanchi Xu, Min Wen, Minghui Li, Dongxin Lyu, Haiming Xiao, Zhuoming Li, Junhui Xiao, Yuanyuan Cheng, Heqing Huang
Publikováno v:
Chinese Medicine, Vol 19, Iss 1, Pp 1-19 (2024)
Abstract Background Heart failure (HF) is characterized by a disorder of cardiomyocyte energy metabolism. Xinbao Pill (XBW), a traditional Chinese medicine formulation integrating “Liushen Pill” and “Shenfu Decoction,” has been approved by Ch
Externí odkaz:
https://doaj.org/article/3389aac0625b4744a2f6730522465955
Autor:
Xinxin Gao, Zhigang Zhu, Yiyang Bao, Yifan Li, Weize Zhu, Xiaofang He, Xinyu Ge, Wenjin Huang, Hao Wang, Wenjing Wei, Jun Du, Liang Chen, Houkai Li, Lili Sheng
Publikováno v:
Chinese Medicine, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Background Chrysanthemum morifolium Ramat, a traditional Chinese medicine, has the effects on liver clearing, vision improving, and anti-inflammation. C. morifolium and probiotics have been individually studied for their beneficial effects o
Externí odkaz:
https://doaj.org/article/8ad179d068fe46ac9529b25778a04fe5
Autor:
Jing Zhang, Guolong Wang, Yuxuan Shi, Xin Liu, Shuang Liu, Wendi Chen, Yunna Ning, Yongzhi Cao, Yueran Zhao, Ming Li
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-18 (2024)
Abstract Background Diabetic cardiomyopathy (DCM) is a crucial complication of long-term chronic diabetes that can lead to myocardial hypertrophy, myocardial fibrosis, and heart failure. There is increasing evidence that DCM is associated with pyropt
Externí odkaz:
https://doaj.org/article/94559552b91244c0acc8a6bc9f5762df
Autor:
Yau-Tuen Chan, Junyu Wu, Yuanjun Lu, Qiucheng Li, Zixin Feng, Lin Xu, Hongchao Yuan, Tingyuan Xing, Cheng Zhang, Hor-Yue Tan, Yibin Feng, Ning Wang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background and aims Sorafenib is a major nonsurgical option for patients with advanced hepatocellular carcinoma (HCC); however, its clinical efficacy is largely undermined by the acquisition of resistance. The aim of this study was to identi
Externí odkaz:
https://doaj.org/article/19f11ffb26aa412a8da62d2485479475
Autor:
Yujia Wei, Xiaomei Zhu, Shan Lin, Wei Yang, Tingmei Wang, Xiaoqi Nie, Zeqi Shi, Zhong Liu, Ri Zhang, Dong Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117129- (2024)
Atopic dermatitis (AD) is a chronic inflammatory skin condition with complex causes involving immune factors. The presence of essential trace elements that support immune system function can influence the development of this condition. This study inv
Externí odkaz:
https://doaj.org/article/93224092dfe74d978ed171cddef9175e
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101978- (2024)
Objective: Aberrant glucolipid metabolism in the heart is a characteristic factor in diabetic cardiomyopathy (DbCM). Super-enhancers-driven noncoding RNAs (seRNAs) are emerging as powerful regulators in the progression of cardiac diseases. However, t
Externí odkaz:
https://doaj.org/article/16456117401a49b0b2898732f1de188d