Zobrazeno 1 - 10
of 5 011
pro vyhledávání: '"pp2a"'
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 7373-7388 (2024)
Wenjuan Yi,1 Qionglin Bao,2 Dingkun Xu,3 Chenyu Long,1 Ruixin Fang,1 Wenlin Cheng,4 Jiquan Song,1 Huiting Feng1 1Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Wound Repair Center, Chronic Woun
Externí odkaz:
https://doaj.org/article/e540d6b27fb24147b014bf877589d9a7
Autor:
Mary C. Clark, Rongze Olivia Lu, Winson S. Ho, Matheus Henrique Dias, René Bernards, Stephen J. Forman
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2333-2337 (2024)
Immune checkpoint blockade has emerged as a potent new tool in the war on cancer. However, only a subset of cancer patients benefit from this therapeutic modality, sparking a search for combination therapies to increase the fraction of responding pat
Externí odkaz:
https://doaj.org/article/08b55194efba462da941ad233f0a4083
Publikováno v:
IBRO Neuroscience Reports, Vol 17, Iss , Pp 423-430 (2024)
Introduction: Neurofibrillary tangles (NFTs) are composed of hyperphosphorylated forms of microtubule-associated protein tau (Tau), which is responsible for neurodegeneration in Alzheimer’s disease (AD). The hippocampal region has been a major focu
Externí odkaz:
https://doaj.org/article/b1ad43a822624b44b8a40b174895f499
Autor:
Guy Nadel, Zhong Yao, Avital Hacohen-Lev-Ran, Ehud Wainstein, Galia Maik-Rachline, Tamar Ziv, Zvi Naor, Arie Admon, Rony Seger
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Although GqPCR activation often leads to cell survival by activating the PI3K/AKT pathway, it was previously shown that in several cell types AKT activity is reduced and leads to JNK activation and apoptosis. The mechanism of AKT
Externí odkaz:
https://doaj.org/article/dc727c91071d45ef97bc3820cc41b6b5
Autor:
Alexandra Nguyen, Al-Hassan M. Mustafa, Alessa K. Leydecker, Melisa Halilovic, Janine Murr, Falk Butter, Oliver H. Krämer
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract As a major source of cellular serine and threonine phosphatase activity, protein phosphatase-2A (PP2A) modulates signaling pathways in health and disease. PP2A complexes consist of catalytic, scaffolding, and B-type subunits. Seventeen PP2A
Externí odkaz:
https://doaj.org/article/9e6174433b8147c5a564a52252e4791f
Publikováno v:
Laboratory Animal Research, Vol 40, Iss 1, Pp 1-8 (2024)
Abstract Background Ischemic stroke is a serious neurological disorder caused by blockages in cerebral artery. Protein phosphatase 2A (PP2A) is a phosphatase that performs a critical role in cell signaling and growth. PP2A subunit B acts as a neuropr
Externí odkaz:
https://doaj.org/article/0c58315c85694bd981e9cf7d1094cbee
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionReversible protein phosphorylation is an abundant post-translational modification dynamically regulated by opposing kinases and phosphatases. Protein phosphorylation has been extensively studied in cell division, where waves of cyclin-dep
Externí odkaz:
https://doaj.org/article/b69505817aa0404796fdcd97197c3098