Zobrazeno 1 - 10
of 102
pro vyhledávání: '"pp242"'
Autor:
Zhaoming Lu, Xiaojing Shi, Fanghua Gong, Shenglei Li, Yang Wang, Yandan Ren, Mengyin Zhang, Bin Yu, Yan Li, Wen Zhao, Jianying Zhang, Guiqin Hou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 1004-1019 (2020)
Dysregulation of mTORC1/mTORC2 pathway is observed in many cancers and mTORC1 inhibitors have been used clinically in many tumor types; however, the mechanism of mTORC2 in tumorigenesis is still obscure. Here, we mainly explored the potential role of
Externí odkaz:
https://doaj.org/article/8f6b8f1c07e542c1b6fac991eebadb85
Akademický článek
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Autor:
Ingrid Vargova, Lucia Machova Urdzikova, Kristyna Karova, Barbora Smejkalova, Tolga Sursal, Veronika Cimermanova, Karolina Turnovcova, Chirag D. Gandhi, Meena Jhanwar-Uniyal, Pavla Jendelova
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 593 (2021)
Traumatic spinal cord injury (SCI) is untreatable and remains the leading cause of disability. Neuroprotection and recovery after SCI can be partially achieved by rapamycin (RAPA) treatment, an inhibitor of mTORC1, complex 1 of the mammalian target o
Externí odkaz:
https://doaj.org/article/85ee2f3dcf7649c683900f46c905c8b8
Autor:
Carmen Mecca, Ileana Giambanco, Stefano Bruscoli, Oxana Bereshchenko, Bernard Fioretti, Carlo Riccardi, Rosario Donato, Cataldo Arcuri
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Glioblastoma multiforme (GBM) is the most malignant brain tumor and is associated with poor prognosis due to its thorny localization, lack of efficacious therapies and complex biology. Among the numerous pathways driving GBM biology studied so far, P
Externí odkaz:
https://doaj.org/article/e9e861125c534a41a4a6ef16f03fafda
Akademický článek
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Akademický článek
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Publikováno v:
Molecules, Vol 23, Iss 11, p 2755 (2018)
We previously reported that PP242 (dual inhibitor of mTORC1/2) plus curcumin induced apoptotic cell death through lysosomal membrane permeabilization (LMP)-mediated autophagy. However, the relationship between ER stress and apoptotic cell death by co
Externí odkaz:
https://doaj.org/article/16b2240b803d434a9f5416ce04168958
Autor:
Becky Pinjou Tsai, Judith Jimenez, Sharon Lim, Kerry D. Fitzgerald, Min Zhang, Charles T. H. Chuah, Haley Axelrod, Luke Nelson, S. Tiong Ong, Bert L. Semler, Marian L. Waterman
Publikováno v:
Open Biology, Vol 4, Iss 11 (2014)
Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined. Lymphoid enhancer factor-1 (LEF-1), a Wnt-mediating transcription fac
Externí odkaz:
https://doaj.org/article/d5d954df2e634b6e95a8558ff0db7719
Publikováno v:
Pharmacological Research
Graphic abstract
Stress granules (SGs) are assemblies of mRNA and proteins that form from mRNAs stalled in translation initiation in response to stress. Chronic stress might even induce formation of cytotoxic pathological SGs. SGs participate in
Stress granules (SGs) are assemblies of mRNA and proteins that form from mRNAs stalled in translation initiation in response to stress. Chronic stress might even induce formation of cytotoxic pathological SGs. SGs participate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80e1d4bdb2336a5aaab712b58bc9286
http://europepmc.org/articles/PMC7428673
http://europepmc.org/articles/PMC7428673
Autor:
Patrizia Leone, Vanessa Desantis, Ilaria Saltarella, Roberto Ria, Antonio Giovanni Solimando, F. Dammacco, Beatrice Nico, Vito Racanelli, Paolo Ditonno, Aurelia Lamanuzzi, Marcella Prete, Angelo Vacca, Domenico Ribatti, Maria Antonia Frassanito
Publikováno v:
Oncotarget
The mammalian Target of Rapamycin (mTOR) is an intracellular serine/threonine kinase that mediates intracellular metabolism, cell survival and actin rearrangement. mTOR is made of two independent complexes, mTORC1 and mTORC2, activated by the scaffol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fb184a06918e0e653f8d10784bd991
https://doi.org/10.18632/oncotarget.25003
https://doi.org/10.18632/oncotarget.25003