Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation

Autor: Zhili Zuo, Li Zhang, Yu Lei, Bin Liu, Hang Xie, Yechun Xu, Sheng Guo

Publikováno v: Bioorganic Chemistry

Graphical abstract
SARS-CoV-2 is the pathogen that caused the global COVID-19 outbreak in 2020. Promising progress has been made in developing vaccines and antiviral drugs. Antivirals medicines are necessary complements of vaccines for post-infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64603f79f7dca1b2529aabbb2a2d9f48
https://pubmed.ncbi.nlm.nih.gov/33667900

Screening and identification of potential MERS-CoV papain-like protease (PLpro) inhibitors; Steady-state kinetic and Molecular dynamic studies.

Autor: Ali Dahhas M; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., M Alkahtani H; Department of Pharmaceutical Chemistry, Department Chairman, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Malik A; Department of Biochemistry, College of Science, King Saud University. King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia., Almehizia AA; Department of Pharmaceutical Chemistry, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Bakheit AH; Department of Pharmaceutical Chemistry, Department Chairman, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Akber Ansar S; Department of Pharmaceutical Chemistry, Department Chairman, P.O. Box 2457, Riyadh 11451, Saudi Arabia., AlAbdulkarim AS; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., S Alrasheed L; Department of Pharmaceutical Chemistry, Department Chairman, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Alsenaidy MA; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Publikováno v: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2023 Feb; Vol. 31 (2), pp. 228-244. Date of Electronic Publication: 2022 Dec 16.