Virus-like particles containing a prefusion-stabilized F protein induce a balanced immune response and confer protection against respiratory syncytial virus infection in mice

Autor: Jin Luo, Huan Qin, Lei Lei, Wange Lou, Ruitong Li, Zishu Pan

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Respiratory syncytial virus (RSV) is a serious respiratory pathogen in infants and young children worldwide. Currently, no licensed RSV vaccines are available. In this study, we explored stable prefusion conformation virus-like particles (Pre-F VLPs)

Externí odkaz: https://doaj.org/article/4bcb25d3830549d0b25592bc51d92a07

Virus-like particles containing a prefusion-stabilized F protein induce a balanced immune response and confer protection against respiratory syncytial virus infection in mice.

Autor: Luo J; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China., Qin H; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China., Lei L; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China., Lou W; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China., Li R; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China., Pan Z; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Dec 12; Vol. 13, pp. 1054005. Date of Electronic Publication: 2022 Dec 12 (Print Publication: 2022).