Zobrazeno 1 - 10
of 9 264
pro vyhledávání: '"post-translational modifications"'
17α-Ethynylestradiol alters testicular epigenetic profiles and histone-to-protamine exchange in mice
Autor:
L. Ded, E. Zatecka-Lanska, E. Vaculikova, M. Frolikova, O. Sanovec, V. Palenikova, O. Simonik, A. Dorosh, H. Margaryan, F. Elzeinova, A. Kubatova, J. Peknicova, A. Paradowska-Dogan, K. Steger, K. Komrskova
Publikováno v:
Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Spermatogenesis starts with the onset of puberty within the seminiferous epithelium of the testes. It is a complex process under intricate control of the endocrine system. Physiological regulations by steroid hormones in general and by estro
Externí odkaz:
https://doaj.org/article/de470ece8aff438a9cf6aa04af3a28ad
Autor:
Francesca Nencini, Alessandra Bettiol, Flavia Rita Argento, Serena Borghi, Elvira Giurranna, Giacomo Emmi, Domenico Prisco, Niccolò Taddei, Claudia Fiorillo, Matteo Becatti
Publikováno v:
Molecular Biomedicine, Vol 5, Iss 1, Pp 1-27 (2024)
Abstract Fibrinogen, a blood plasma protein with a key role in hemostasis and thrombosis, is highly susceptible to post-translational modifications (PTMs), that significantly influence clot formation, structure, and stability. These PTMs, which inclu
Externí odkaz:
https://doaj.org/article/e592e11f827e42dbac53eb8d481136da
Autor:
Yasaman Karami, Emmanuelle Bignon
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1387-1396 (2024)
Gene activity is tightly controlled by reversible chemical modifications called epigenetic marks, which are of various types and modulate gene accessibility without affecting the DNA sequence. Despite an increasing body of evidence demonstrating the
Externí odkaz:
https://doaj.org/article/3778777b88da441782bb2162a4dae38f
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-22 (2024)
Abstract Breast cancer represents the most prevalent tumor type and a foremost cause of mortality among women globally. The complex pathophysiological processes of breast cancer tumorigenesis and progression are regulated by protein post-translationa
Externí odkaz:
https://doaj.org/article/70edaf1f8d1b487a917343567ea172f1
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1652-1670 (2024)
This review article aims to highlight the role of methyltransferases within the context of ribosomally synthesised and post-translationally modified peptide (RiPP) natural products. Methyltransferases play a pivotal role in the biosynthesis of divers
Externí odkaz:
https://doaj.org/article/3a16fd771d7943b3893ad6752fbb83c1
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Liver cancer is a significant global health challenge, with hepatocellular carcinoma (HCC) being the most prevalent form, characterized by high incidence and mortality rates. Despite advances in targeted therapies and immunotherapies, the pr
Externí odkaz:
https://doaj.org/article/52687e5a483b44188bdff0f44927059a
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 4315-4330 (2024)
Chenguang Jia,1,* Xiaowei Yao,1,* Zhaoliang Dong,1 Lianbo Wang,1 Fangchao Zhao,2,* Jianguo Gao,1,* Tao Cai3,* 1Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Thor
Externí odkaz:
https://doaj.org/article/02929106a75142e4bd53ac33b1cc097e
Autor:
Yulia V. Stepenko, Veronika S. Shmigerova, Darya A. Kostina, Olesya V. Shcheblykina, Nina I. Zhernakova, Alexey V. Solin, Natalia V. Koroleva, Vera A. Markovskaya, Olga V. Dudnikova, Anton A. Bolgov
Publikováno v:
Research Results in Pharmacology, Vol 10, Iss 2, Pp 41-47 (2024)
Introduction: Tau proteinopathy is a pathology associated with the activation of post-translational modifications and interactions of pathophysiological cascades of neuroinflammation with hyperphosphorylation of Tau aggregates. Therefore, preference
Externí odkaz:
https://doaj.org/article/748371325e0247c8bea4efff0cbc31f5
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 6, Pp 475-483 (2024)
ERK1/2 is a key protein that mediates cell signal transduction, and it is involved in regulating biological processes such as chromatin remodeling, nuclear disintegration, proliferation, survival, metabolism, and cell migration and differentiation. I
Externí odkaz:
https://doaj.org/article/df39793afbe54add9d50f077e6256191
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-15 (2024)
Abstract Background Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological processes that would otherwise be impossible. The challenging nature of certain nuclear proteins includes low ab
Externí odkaz:
https://doaj.org/article/19de9942344745358a8999691b1518a9