Zobrazeno 1 - 10
of 1 098
pro vyhledávání: '"post-translational modification (PTM)"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Colorectal cancer is a leading cause of cancer-related mortality worldwide. Traditionally, colorectal cancer has been recognized as a disease caused by genetic mutations. However, recent studies have revealed the significant role of epigenet
Externí odkaz:
https://doaj.org/article/924ae2f767e34e4e981d3f4876ce1457
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/fa0648581e0f4609a3ac1262f004e715
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Upon infection of host cells the Legionella pneumophila bacterium releases a multitude of effector enzymes into the host’s cytoplasm that manipulate cellular host pathways, including the host-ubiquitination pathways. The effectors belonging to the
Externí odkaz:
https://doaj.org/article/f1061b96b73b4f8696b0e66e4cd73ec0
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32517- (2024)
Ubiquitination is an essential post-translational modification mechanism involving the ubiquitin protein's bonding to a substrate protein. It is crucial in a variety of physiological activities including cell survival and differentiation, and innate
Externí odkaz:
https://doaj.org/article/6f31b15104704d37a20960b598ec2888
Autor:
Mullen Boulter, Kyle K. Biggar
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1112 (2024)
The dual methyltransferase methyltransferase-like protein 13, also referred to as METTL13, or formerly known as FEAT (faintly expressed in healthy tissues, aberrantly overexpressed in tumors), has garnered attention as a significant enzyme in various
Externí odkaz:
https://doaj.org/article/bcae9e1029984d6099a3e6b7e01f64f8
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
It is commonly known that different macrophage phenotypes play specific roles in different pathophysiological processes. In recent years, many studies have linked the phenotypes of macrophages to their characteristics in different metabolic pathways,
Externí odkaz:
https://doaj.org/article/249e14b0fe814e77b894dafdb58457fe
Autor:
Ruqi Tan, Dandan Li, Nan Hu, Jing Qiu, Zhipeng Zeng, Wanxia Cai, Yafang Zhong, Xinzhou Zhang, Pearl Pai, Kang Wang, Donge Tang, Yong Dai
Publikováno v:
Proteome Science, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background End-stage renal disease (ESRD) is a condition that is characterized by the loss of kidney function. ESRD patients suffer from various endothelial dysfunctions, inflammation, and immune system defects. Lysine malonylation (Kmal) is
Externí odkaz:
https://doaj.org/article/b209d637ea3d46eab1eb09b31091cf1f
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8873 (2024)
Nitric oxide (NO) has been firmly established as a key signaling molecule in plants, playing a significant role in regulating growth, development and stress responses. Given the imperative of sustainable agriculture and the urgent need to meet the es
Externí odkaz:
https://doaj.org/article/e7b9c4d2f1ea435384e00aae0c1382bb
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
Parkinson’s disease (PD) is the second most common neurodegenerative disease with currently no cure. Most PD cases are sporadic, and about 5–10% of PD cases present a monogenic inheritance pattern. Mutations in more than 20 genes are associated w
Externí odkaz:
https://doaj.org/article/e48b704dc34743ccb056568daae3516b
Publikováno v:
Biomolecules & Biomedicine (2024)
The inflammatory response is a natural immune response that prevents microbial invasion and repairs damaged tissues. However, excessive inflammatory responses can lead to various inflammation-related diseases, posing a significant threat to human hea
Externí odkaz:
https://doaj.org/article/87bc9310c2f64908978c4cee340f2e41