Zobrazeno 1 - 10
of 761
pro vyhledávání: '"post-transcriptional gene regulation"'
Autor:
Amit K. Jaiswal, Michelle L. Thaxton, Georgia M. Scherer, Jacob P. Sorrentino, Neil K. Garg, Dinesh S. Rao
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-14 (2024)
ABSTRACTIn recent years, advances in biomedicine have revealed an important role for post-transcriptional mechanisms of gene expression regulation in pathologic conditions. In cancer in general and leukaemia specifically, RNA binding proteins have em
Externí odkaz:
https://doaj.org/article/37f8ee50b32748519cd1e2eefcd9acb6
Autor:
Pascal Forcella, Niklas Ifflander, Chiara Rolando, Elli-Anna Balta, Aikaterini Lampada, Claudio Giachino, Tanzila Mukhtar, Thomas Bock, Verdon Taylor
Publikováno v:
eLife, Vol 13 (2024)
Neural stem cells (NSCs) are multipotent and correct fate determination is crucial to guarantee brain formation and homeostasis. How NSCs are instructed to generate neuronal or glial progeny is not well understood. Here, we addressed how murine adult
Externí odkaz:
https://doaj.org/article/c62f42c3773d4eb489e0343720bc40a9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
RNA binding proteins (RBPs) play a central in the post-transcriptional regulation of gene expression, which can account for up to 50% of all variations in protein expression within a cell. Following their binding to target RNAs, RBPs most typically c
Externí odkaz:
https://doaj.org/article/2e2fbf0d4c2c4dc8964cd82bb5675cb3
Autor:
Louis R. Parham, Patrick A. Williams, Kay Katada, Shaneice K. Nettleford, Priya Chatterji, Kofi K. Acheampong, Charles H. Danan, Xianghui Ma, Lauren A. Simon, Kaitlyn E. Naughton, Rei Mizuno, Tatiana Karakasheva, Emily A. McMillan, Kelly A. Whelan, Donita C. Brady, Sydney M. Shaffer, Kathryn E. Hamilton
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 439-451 (2024)
Background & Aims: The intestinal epithelium interfaces with a diverse milieu of luminal contents while maintaining robust digestive and barrier functions. Facultative intestinal stem cells are cells that survive tissue injury and divide to re-establ
Externí odkaz:
https://doaj.org/article/2d55833f363e489b8c29b533990b04ea
Publikováno v:
Orthopaedic Surgery, Vol 15, Iss 12, Pp 3015-3025 (2023)
The etiology of intervertebral disc degeneration (IDD) and osteoarthritis (OA) is complex and multifactorial. Both predisposing genes and environmental factors are involved in the pathogenesis of IDD and OA. Moreover, epigenetic modifications affect
Externí odkaz:
https://doaj.org/article/c2eb0a1dcf5c45788c8da2051dc14626
Autor:
Neda Zolfaghari Khutbehsera, Mohammad Mohsenzadeh Golfazani, Mohammad Mehdi Taghvaei, Habibollah Samizadeh Lahiji
Publikováno v:
مجله بیوتکنولوژی کشاورزی, Vol 14, Iss 4, Pp 103-132 (2022)
ObjectiveAbiotic stresses such as drought and salinity significantly affect plant growth and performance. Plants use strategies to adapt and tolerate drought and salt stress that may threaten their survival during their life cycle, one of which is mi
Externí odkaz:
https://doaj.org/article/10ada6bf1161415192ca922aef0e48a3
Autor:
Vikram Agarwal, David R. Kelley
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background Degradation rate is a fundamental aspect of mRNA metabolism, and the factors governing it remain poorly characterized. Understanding the genetic and biochemical determinants of mRNA half-life would enable more precise identificati
Externí odkaz:
https://doaj.org/article/18fa8294a0a7414aab75010d100619fb
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-10 (2022)
Abstract Background AU-rich elements (AREs) are located in the 3′UTRs of 22% of human mRNAs, including most transiently expressed inflammatory mediators. By default, AREs mark mRNAs for decay and translational inhibition, but this activity can be t
Externí odkaz:
https://doaj.org/article/dfabde5d889f4cc88972b3d535e917f9
Autor:
Attila A. Seyhan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1469 (2024)
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases, particularly various cancer types, has generated significant interest in exploring their potential as a novel class of drugs. This has led to substantial investments
Externí odkaz:
https://doaj.org/article/c6ff19ab36594914a44839e9b9642a8c
Autor:
Ji Won Lee, Hyejin Mun, Jeong-Hyun Kim, Seungbeom Ko, Young-Kook Kim, Min Ji Shim, Kyungmin Kim, Chul Woong Ho, Hyun Bong Park, Meesun Kim, Chaeyoung Lee, Si Ho Choi, Jung-Woong Kim, Ji-Hoon Jeong, Je-Hyun Yoon, Kyung-Won Min, Tae Gen Son
Publikováno v:
Biology, Vol 12, Iss 12, p 1533 (2023)
Although ionizing radiation (IR) is widely used for therapeutic and research purposes, studies on low-dose ionizing radiation (LDIR) are limited compared with those on other IR approaches, such as high-dose gamma irradiation and ultraviolet irradiati
Externí odkaz:
https://doaj.org/article/d498601a00054471b02e912aa1032671