Zobrazeno 1 - 10
of 7 735
pro vyhledávání: '"post‐transcriptional regulation"'
Autor:
Daniel del Valle-Morales, Giulia Romano, Giovanni Nigita, Michela Saviana, Alessandro La Ferlita, Patricia Le, Rachel Brown, Lavender Micalo, Howard Li, Patrick Nana-Sinkam, Mario Acunzo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The 5’ cap, catalyzed by RNA guanylyltransferase and 5’-phosphatase (RNGTT), is a vital mRNA modification for the functionality of mRNAs. mRNA capping occurs in the nucleus for the maturation of the functional mRNA and in the cytoplasm f
Externí odkaz:
https://doaj.org/article/1393fe678efa464480c300798d097763
Autor:
Roswitha Dolcemascolo, Raúl Ruiz, Sara Baldanta, Lucas Goiriz, María Heras-Hernández, Roser Montagud-Martínez, Guillermo Rodrigo
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-11 (2024)
Abstract RNA recognition motifs (RRMs) are widespread RNA-binding protein domains in eukaryotes, which represent promising synthetic biology tools due to their compact structure and efficient activity. Yet, their use in prokaryotes is limited and the
Externí odkaz:
https://doaj.org/article/a029a97bc8f84f8d983d20ef3d793484
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract Biological systems encompass intricate networks governed by RNA-protein interactions that play pivotal roles in cellular functions. RNA and proteins constituting 1.1% and 18% of the mammalian cell weight, respectively, orchestrate vital proc
Externí odkaz:
https://doaj.org/article/09c2c9fc5ead49d4bc4798e3359bfa42
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 14-23 (2024)
The estrogen signalling pathway is highly dynamic and primarily mediated by estrogen receptors (ERs) that transcriptionally regulate the expression of target genes. While transcriptional functions of ERs have been widely studied, their roles in RNA b
Externí odkaz:
https://doaj.org/article/7d1a054dec2749678b78a2be4e5caf14
Autor:
Yanke Jiang, Yingzhe Yue, Chongchong Lu, Muhammad Zunair Latif, Haifeng Liu, Zhaoxu Wang, Ziyi Yin, Yang Li, Xinhua Ding
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Pre-mRNA splicing is a significant step for post-transcriptional modifications and functions in a wide range of physiological processes in plants. Human NHP2L binds to U4 snRNA during spliceosome assembly; it is involved in RNA splicing and
Externí odkaz:
https://doaj.org/article/8a77a0ec23684005adfaa8c5bdfd3e5e
Autor:
Ting-Wen Chen, Hsiao-Wei Liao, Michelle Noble, Jing-Yi Siao, Yu-Hsuan Cheng, Wei-Chung Chiang, Yi-Tzu Lo, Chung-Te Chang
Publikováno v:
eLife, Vol 13 (2024)
The mRNA 5'-cap structure removal by the decapping enzyme DCP2 is a critical step in gene regulation. While DCP2 is the catalytic subunit in the decapping complex, its activity is strongly enhanced by multiple factors, particularly DCP1, which is the
Externí odkaz:
https://doaj.org/article/d86b4709c5e24078b6c55c1cecddbc6e
Autor:
Namita Mukundan, Nivedita Hariharan, Vidyanand Sasidharan, Vairavan Lakshmanan, Dasaradhi Palakodeti, Colin Jamora
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Post-transcriptional regulation has emerged as a key mechanism for regulating stem cell renewal and differentiation, which is essential for understanding tissue regeneration and homeostasis. Poly(A)-binding proteins are a family of RNA-binding protei
Externí odkaz:
https://doaj.org/article/14e71d3ac4f641b49497bbe4459072c6
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101807- (2024)
The fate and stability of messenger RNA (mRNA), from transcription to degradation is regulated by a dynamic shuttle of epigenetic modifications and RNA binding proteins in maintaining healthy cellular homeostasis and disease development. While Transf
Externí odkaz:
https://doaj.org/article/54cff313593c475398c3737930d5f897
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101252- (2024)
Hematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitud
Externí odkaz:
https://doaj.org/article/9f7bac4185db460f9815d546b8cf18ae
Autor:
Jin Zhang, Lingling Tong, Yuchen Liu, Xiang Li, Jiayi Wang, Ruoxin Lin, Ziyu Zhou, Yunbing Chen, Yanxi Chen, Yirong Liu, Di Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101199- (2024)
As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs, N6-methyladenosine (m6A) post-transcriptionally regulates the processing and metabolism of mRNAs involved in diverse biological processes. m6A modification is
Externí odkaz:
https://doaj.org/article/61c0d7e0e6d045f1be238f270384276c