cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants.

Autor: Olivares-González, Lorena^1,2, Martínez-Fernández de la Cámara, Cristina¹, Hervás, David³, Marín, María Pilar⁴, Lahoz, Agustin⁵, Millán, José María^1,2, Rodrigo, Regina^1,2 regina.rodrigo@yahoo.es

Publikováno v: PLoS ONE. 11/18/2016, Vol. 11 Issue 11, p1-21. 21p.

cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants.

Autor: Lorena Olivares-González, Cristina Martínez-Fernández de la Cámara, David Hervás, María Pilar Marín, Agustin Lahoz, José María Millán, Regina Rodrigo

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166717 (2016)

Retinal hypoxia and oxidative stress are involved in several retinal degenerations including diabetic retinopathy, glaucoma, central retinal artery occlusion, or retinopathy of prematurity. The second messenger cyclic guanosine monophosphate (cGMP) h

Externí odkaz: https://doaj.org/article/cf42187bb8aa4a45ae87ea861036b353

cGMP-phosphodiesterase inhibition prevents hypoxia-induced cell death activation in porcine retinal explants

Autor: María Pilar Marín, Cristina Martinez-Fernandez de la Camara, Regina Rodrigo, Agustín Lahoz, José M. Millán, David Hervás, Lorena Olivares-González

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166717 (2016)
Plos One
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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PLoS ONE

Retinal hypoxia and oxidative stress are involved in several retinal degenerations including diabetic retinopathy, glaucoma, central retinal artery occlusion, or retinopathy of prematurity. The second messenger cyclic guanosine monophosphate (cGMP) h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b75ed385d5264c6df658fd9f309276
https://doi.org/10.1371/journal.pone.0166717

Specific inhibition of TRPV4 enhances retinal ganglion cell survival in adult porcine retinal explants

Autor: Fredrik Ghosh, Karin Arnér, Linnéa Taylor

Publikováno v: Experimental Eye Research; 154, pp 10-21 (2017)

Signaling through the polymodal cation channel Transient Receptor Potential Vanilloid 4 (TRPV4) has been implicated in retinal neuronal degeneration. To further outline the involvement of this channel in this process, we here explore modulation of Tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c286653e2508a0a1e9a043c87d898e
https://lup.lub.lu.se/record/47c746fc-dc06-4954-891f-eff9fe652e53

Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model

Autor: Angela Armento, Aparna Murali, Julia Marzi, Ana C Almansa-Garcia, Blanca Arango-Gonzalez, Ellen Kilger, Simon J Clark, Katja Schenke-Layland, Charmaine A Ramlogan-Steel, Jason C Steel, Marius Ueffing

Publikováno v: Biomolecules, Vol 11, Iss 11, p 1621 (2021)

Age-related Macular degeneration (AMD) is a degenerative disease of the macula affecting the elderly population. Treatment options are limited, partly due to the lack of understanding of AMD pathology and the lack of suitable research models that rep

Externí odkaz: https://doaj.org/article/536089fdaf7f41d9979efdbcd4ffd47f