Zobrazeno 1 - 10
of 311
pro vyhledávání: '"porcine endogenous retroviruses"'
Autor:
Joachim Denner
Publikováno v:
Transplant International, Vol 37 (2024)
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs. PERV-A, PERV-B and PERV-C can be released as infectious virus particles and PERV-A and PERV-B can infect human cells in culture. PERV-C does not infect human cells, but
Externí odkaz:
https://doaj.org/article/306d4915ca074676b332d747217873a5
Publikováno v:
Viruses, Vol 16, Iss 7, p 1119 (2024)
Detection methods have been developed to prevent transmission of zoonotic or xenozoonotic porcine viruses after transplantation of pig organs or cells to the recipient (xenotransplantation). Eleven xenotransplantation-relevant viruses, including porc
Externí odkaz:
https://doaj.org/article/6fa1d6d71502410ab0ce8a82d3b79d03
Autor:
Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner
Publikováno v:
Microorganisms, Vol 12, Iss 2, p 315 (2024)
The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient. To validate these m
Externí odkaz:
https://doaj.org/article/09795f74e2e845b7b6fb8953ed071303
Publikováno v:
Microorganisms, Vol 12, Iss 1, p 98 (2024)
Auckland Island pigs represent an inbred population of feral pigs isolated on the sub-Antarctic island for over 100 years. The animals have been maintained under pathogen-free conditions in New Zealand; they are well characterized virologically and h
Externí odkaz:
https://doaj.org/article/7d9a752acf934c8b89d4365a3f881310
Autor:
Sabrina Halecker, Ludwig Krabben, Yannick Kristiansen, Luise Krüger, Lars Möller, Dietmar Becher, Michael Laue, Benedikt Kaufer, Christian Reimer, Joachim Denner
Publikováno v:
Virology Journal, Vol 19, Iss 1, Pp 1-13 (2022)
Abstract Background Porcine endogenous retroviruses (PERVs) can infect human cells and pose a risk for xenotransplantation when pig cells, tissues or organs are transplanted to human recipients. Xenotransplantation holds great promise to overcome the
Externí odkaz:
https://doaj.org/article/2a398a1708a44e19ba2ab5553c9c84a4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation. Most current studies mainly focus on genetical
Externí odkaz:
https://doaj.org/article/676566ca18304086a230e6d761a0a185
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Hina Jhelum, Martin Bender, Bruno Reichart, Maren Mokelke, Julia Radan, Elisabeth Neumann, Ludwig Krabben, Jan-Michael Abicht, Benedikt Kaufer, Matthias Längin, Joachim Denner
Publikováno v:
Viruses, Vol 15, Iss 7, p 1618 (2023)
Xenotransplantation, like allotransplantation, is usually associated with microchimerism, i.e., the presence of cells from the donor in the recipient. Microchimerism was reported in first xenotransplantation trials in humans, as well as in most precl
Externí odkaz:
https://doaj.org/article/a68569324e2146edaafc5ad5c5ed0d78
Autor:
Joachim Denner
Publikováno v:
Viruses, Vol 15, Iss 1, p 190 (2023)
Microchimerism is the presence of cells in an individual that have originated from a genetically distinct individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establ
Externí odkaz:
https://doaj.org/article/21c5170473384d7ebd8c5bd4159f6d91
Autor:
Shuwen Zheng, Haiwen Zhong, Xiaoqing Zhou, Min Chen, Wansheng Li, Yin Zi, Yue Chi, Jinling Wang, Wei Zheng, Qingjian Zou, Liangxue Lai, Chengcheng Tang
Publikováno v:
Cells, Vol 11, Iss 24, p 3975 (2022)
Gene-modified miniature pigs serve as alternative tissue and organ donors for xenotransplantation to alleviate the shortage of human allogenic organs. However, the high copy number of porcine endogenous retrovirus (PERV) genomes integrates with the p
Externí odkaz:
https://doaj.org/article/26540f3facf84010ade8ca369d5b957b