Zobrazeno 1 - 10
of 2 861
pro vyhledávání: '"polypharmacology"'
Autor:
Manen-Freixa L; Oncobell Division, Bellvitge Biomedical Research Institute (IDIBELL) and ProCURE Department, Catalan Institute of Oncology (ICO), Barcelona, Spain., Antolin AA; Oncobell Division, Bellvitge Biomedical Research Institute (IDIBELL) and ProCURE Department, Catalan Institute of Oncology (ICO), Barcelona, Spain.; Center for Cancer Drug Discovery, The Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.
Publikováno v:
Expert opinion on drug discovery [Expert Opin Drug Discov] 2024 Sep; Vol. 19 (9), pp. 1043-1069. Date of Electronic Publication: 2024 Jul 14.
Autor:
Li Z; College of Computer and Information Engineering, Dezhou University, Dezhou City 253023, China.; Development Department, Suzhou Alphama Biotechnology Co., Ltd, Suzhou City 215000, China., Qu N; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China., Zhou J; School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Lingang Laboratory, Shanghai 200031, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China., Sun J; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China., Ren Q; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China., Meng J; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China., Wang G; College of Computer and Information Engineering, Dezhou University, Dezhou City 253023, China., Wang R; College of Computer and Information Engineering, Dezhou University, Dezhou City 253023, China., Liu J; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China., Chen Y; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China., Zhang S; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China., Zheng M; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China., Li X; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China.
Publikováno v:
Nucleic acids research [Nucleic Acids Res] 2024 Jul 05; Vol. 52 (W1), pp. W489-W497.
Autor:
López-López E; Department of Chemistry and Graduate Program in Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute, Section 14-740, Mexico City 07000, Mexico; DIFACQUIM Research Group, Department of Pharmacy, School of Chemistry, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. Electronic address: elopez.lopez@cinvestav.mx., Medina-Franco JL; DIFACQUIM Research Group, Department of Pharmacy, School of Chemistry, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. Electronic address: medinajl@unam.mx.
Publikováno v:
Drug discovery today [Drug Discov Today] 2024 Jul; Vol. 29 (7), pp. 104046. Date of Electronic Publication: 2024 May 27.
Autor:
Rafehi M; Department of Medical Education Augsburg, Augsburg University Medicine, Stenglinstr. 2, 86156, Augsburg, Germany. muhammad.rafehi@med.uni-augsburg.de.; Institute of Clinical Pharmacology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany. muhammad.rafehi@med.uni-augsburg.de., Möller M; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck and University Medical Center Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Germany., Ismail Al-Khalil W; Institute of Clinical Pharmacology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany., Stefan SM; Medicinal Chemistry and Systems Polypharmacology, Medical Systems Biology Division, Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck and University Medical Center Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Germany. sven.stefan@uni-luebeck.de.; Department of Pathology, University of Oslo and Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway. sven.stefan@uni-luebeck.de.; Department of Biopharmacy, Medical University of Lublin, Chodzki 4a, Lublin, 20-093, Poland. sven.stefan@uni-luebeck.de.
Publikováno v:
Pharmaceutical research [Pharm Res] 2024 Mar; Vol. 41 (3), pp. 411-417. Date of Electronic Publication: 2024 Feb 16.
Autor:
Chen Z; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Yu J; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Wang H; iHuman Institute, ShanghaiTech University, Shanghai 201210, China., Xu P; State Key Laboratory of Drug Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Fan L; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China., Sun F; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Huang S; State Key Laboratory of Drug Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Zhang P; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Huang H; ComMedX, Beijing 100094, China., Gu S; ComMedX, Beijing 100094, China., Zhang B; ComMedX, Beijing 100094, China., Zhou Y; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Wan X; ComMedX, Beijing 100094, China., Pei G; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Xu HE; State Key Laboratory of Drug Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: eric.xu@simm.ac.cn., Cheng J; iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: chengjj@shanghaitech.edu.cn., Wang S; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address: wangsheng@sibcb.ac.cn.
Publikováno v:
Cell [Cell] 2024 Apr 25; Vol. 187 (9), pp. 2194-2208.e22. Date of Electronic Publication: 2024 Mar 28.
Autor:
Maddeboina K; Molecular Targeted Therapeutics Laboratory, Levine Cancer Institute/Atrium Health, Charlotte, NC 28204, USA; Department of Biochemistry, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA. Electronic address: Krishnaiah.maddeboina@atriumhealth.org., Yada B; Molecular Targeted Therapeutics Laboratory, Levine Cancer Institute/Atrium Health, Charlotte, NC 28204, USA., Kumari S; Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520, USA., McHale C; Molecular Targeted Therapeutics Laboratory, Levine Cancer Institute/Atrium Health, Charlotte, NC 28204, USA., Pal D; Molecular Targeted Therapeutics Laboratory, Levine Cancer Institute/Atrium Health, Charlotte, NC 28204, USA., Durden DL; Molecular Targeted Therapeutics Laboratory, Levine Cancer Institute/Atrium Health, Charlotte, NC 28204, USA; Department of Biochemistry, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA. Electronic address: donald.durden@atriumhealth.org.
Publikováno v:
Drug discovery today [Drug Discov Today] 2024 Mar; Vol. 29 (3), pp. 103904. Date of Electronic Publication: 2024 Jan 26.
Autor:
Amandy FV; The Graduate School, University of Santo Tomas, España Blvd., Manila 1015, Philippines.; Laboratory for Organic Reactivity, Discovery and Synthesis (Rm. 410), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana Blvd., Manila 1015, Philippines.; Department of Chemistry, College of Science, Adamson University, San Marcelino St., Ermita, Manila 1000, Philippines., Neri GLL; Laboratory for Organic Reactivity, Discovery and Synthesis (Rm. 410), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana Blvd., Manila 1015, Philippines., Manzano JAH; The Graduate School, University of Santo Tomas, España Blvd., Manila 1015, Philippines.; Laboratory for Organic Reactivity, Discovery and Synthesis (Rm. 410), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana Blvd., Manila 1015, Philippines., Go AD; Laboratory for Organic Reactivity, Discovery and Synthesis (Rm. 410), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana Blvd., Manila 1015, Philippines.; Department of Chemistry, College of Science, Adamson University, San Marcelino St., Ermita, Manila 1000, Philippines., Macabeo APG; Laboratory for Organic Reactivity, Discovery and Synthesis (Rm. 410), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana Blvd., Manila 1015, Philippines.
Publikováno v:
Current drug targets [Curr Drug Targets] 2024; Vol. 25 (9), pp. 620-634.
Autor:
Zhou M; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Jiao Q; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Wu Z; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Li W; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Liu G; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Wang R; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Tang Y; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Publikováno v:
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 99 (s1), pp. S139-S156.
Autor:
Gartan P; Department of Chemistry, University of Bergen, Bergen 5020, Norway.; Computational Biology Unit, University of Bergen, Bergen 5020, Norway., Khorsand F; Department of Biomedicine, University of Bergen, Bergen 5020, Norway., Mizar P; Department of Chemistry, University of Bergen, Bergen 5020, Norway., Vahokovski JI; Core Facility for Biophysics, Structural Biology, and Screening, Department of Biomedicine, University of Bergen, Bergen 5020, Norway., Cervantes LF; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Haug BE; Department of Chemistry, University of Bergen, Bergen 5020, Norway.; Centre for Pharmacy, University of Bergen, Bergen 5020, Norway., Brenk R; Department of Biomedicine, University of Bergen, Bergen 5020, Norway., Brooks CL 3rd; Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.; Biophysics Program, University of Michigan, Ann Arbor, Michigan 48109, United States., Reuter N; Department of Chemistry, University of Bergen, Bergen 5020, Norway.; Computational Biology Unit, University of Bergen, Bergen 5020, Norway.
Publikováno v:
Journal of chemical information and modeling [J Chem Inf Model] 2024 Feb 12; Vol. 64 (3), pp. 621-626. Date of Electronic Publication: 2024 Jan 26.
Autor:
Cichońska A; Harmonic Discovery Inc., New York, United States. Electronic address: anna@harmonicdiscovery.com., Ravikumar B; Harmonic Discovery Inc., New York, United States., Rahman R; Harmonic Discovery Inc., New York, United States.
Publikováno v:
Current opinion in structural biology [Curr Opin Struct Biol] 2024 Feb; Vol. 84, pp. 102771. Date of Electronic Publication: 2024 Jan 11.